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@djspinnest: one of my favorite from the man Daasebre RIP
djspinnest
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Region: GH
Thursday 09 December 2021 16:51:19 GMT
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Comments
•||•EFYASKRILLA•||•🤑 :
🥰🥰🥰
2022-01-04 11:50:53
1
Isaac Ashanti :
✌️🥰🥰
2024-03-01 13:49:29
1
djspinnest :
❤️❤️❤️
2021-12-18 19:00:11
0
To see more videos from user @djspinnest, please go to the Tikwm homepage.
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Research has identified an inflammatory subtype of major depressive disorder. A 2019 meta-analysis (Osimo et al., 37 studies, 13,541 patients) found 27% of depressed patients have low-grade inflammation (CRP >3 mg/L) and 58% have mildly elevated CRP. Pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1β) can cross the blood-brain barrier and activate the kynurenine pathway, diverting tryptophan away from serotonin synthesis. A 2024 review in Cells (DOI: 10.3390/cells13050423) outlines how peripheral and central inflammation, combined with gut microbiota dysbiosis, contribute to depression through impaired neuroplasticity and serotonin disruption. A 2024 protocol study in Brain, Behavior, and Immunity describes ‘immuno-metabolic depression’ as a distinct subtype with characteristic symptoms (increased appetite, weight gain, fatigue) and elevated inflammatory markers. Important: Most depression treatments still target neurotransmitter systems and remain effective for many patients. The inflammatory subtype is emerging research that runs alongside the established model, not instead of it. Anti-inflammatory drugs are not FDA-approved as antidepressants. I’m not a doctor, just sharing research I find interesting. Sources: Osimo et al. (2019). Brain, Behavior, and Immunity. Roman et al. (2024). Cells. DOI: 10.3390/cells13050423 Cattaneo et al. (2024). Brain, Behavior, and Immunity. #depressionanxiety #chronicillness #MentalHealth #inflammation
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