@seed: Did you know that olive oil can function similarly to Ozempic? 🫒🤔 To understand how, you'll need to learn about GLP-1, a protein that's been making headlines alongside the weight-loss medication. GLP-1 is a small protein that your gut produces to signal satiety to other parts of your body. Think of the GLP-1 receptor (the protein that GLP-1 binds to) as the natural “full” button in your brain and GLP-1 as the finger that presses the button.👇Ozempic is the synthetic version of this, making you feel full by artificially pushing that button. The foods we eat can also trigger GLP-1—which brings us back to olive oil. Fat-rich foods generally stimulate GLP-1 release better than carbs. A 2015 study, which looked at 12 healthy men, showed that feeding these men olive oil (with a bit of shredded carrot) was enough to induce a major spike in GLP-1 levels naturally, leading to sensations of satiety similar to the ones Ozempic creates pharmaceutically. 🤯 While this study is admittedly small and not generalizable—for one, it didn't include any women—it suggests that there's a relationship between olive oil and the release of GLP-1, at least in some people. But it may not be the olive oil by itself that’s responsible: Rather, certain gut bacteria break down a compound in olive oil, called oleic acid, to accomplish this. Here’s how it works: 1️⃣ Gemella (a type of bacteria in the gut) breaks down oleic acid into a byproduct, or metabolite, called oleoyl serinol. 2️⃣ Oleoyl serinol stimulates the release of GLP-1 by intestinal cells. So why does this all matter? While the cultural conversation around Ozempic has focused on weight loss, the impact of satiety isn’t just about body size and appearance. Your body and your microbes work together every day to utilize the foods you eat to help you feel full and energetic. Understanding the incredible ways in which satiety can be mediated by the microbiome can help you better understand, nourish, and power your own body. Want to learn more? Drop your questions in the comments. #oliveoil #ozempic

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Thursday 19 October 2023 15:17:55 GMT