@drsermedmezher: How a Man’s DNA Can Permanently Change the Mother of His Children #transfer. Epigenetic changes can indeed be long-lasting and even heritable, contributing to the regulation of gene expression over multiple generations. While some epigenetic modifications are reversible and dynamic, others can become more stable and even permanent under certain conditions. Here's a description of how permanent epigenetic changes can be made to DNA in the presence of altered conditions: DNA Methylation: DNA methylation involves the addition of methyl groups to specific cytosine residues within DNA, typically occurring at CpG dinucleotides. While DNA methylation patterns are dynamically regulated throughout development and in response to environmental cues, certain methyl marks can become more stable and resistant to removal, leading to long-lasting changes in gene expression. This process, known as "maintenance methylation," ensures the stability of epigenetic modifications across cell divisions and can contribute to the inheritance of epigenetic traits. Histone Modifications: Histone modifications, such as methylation, acetylation, phosphorylation, and ubiquitination, can also exhibit long-lasting effects on chromatin structure and gene expression. Some histone modifications are associated with transcriptionally active or repressive chromatin states and can persist through multiple cell divisions, influencing gene expression patterns over time. Stable histone modifications can be maintained by histone-modifying enzymes and chromatin remodeling complexes, ensuring the stability of epigenetic states. Imprinting: Imprinting is a form of epigenetic regulation that involves the differential methylation and expression of genes based on their parental origin. Imprinted genes typically exhibit parent-of-origin-specific expression patterns, with one allele being silenced through DNA methylation or histone modification. Imprinting marks are established during gametogenesis and are maintained throughout development and adulthood, resulting in long-lasting and heritable epigenetic modifications that influence gene expression. #dna #couple

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Monday 01 April 2024 19:37:01 GMT