@mr._apbio: Let's try this again...ligand gated ion channels let ions flow across the membrane's phospholipid bilayer. Normally they can not cross the hydrophobic nonpolar core. This provides a hydrophilic region in which to pass. Voltage gated channels can do the same. Note: This contributes to the regulatory mechanisms that lead to the membranes semi-permeable nature.#bio101 #cellularbiology #impenetrable #ligand #facilitateddiffusion #transport #apbiology #apbio #apbioexam