@chemedits: are you made of RNA? because uracil-ly goose😝 "Transcription initiation is the phase during which the first nucleotides in the RNA chain are synthesized. It is a multistep process that starts when the RNAP holoenzyme binds to the DNA template and ends when the core polymerase escapes from the promoter after the synthesis of approximately the first nine nucleotides. The stages of the transcription initiation process, which are summarized in Figure 2, can be described in terms of the types of interaction between the RNAP and the nucleic acids that are involved. The first stage in transcription initiation is the formation of a complex between the holoenzyme and the DNA sequence at the promoter, which is in the form of a double-stranded DNA. This complex is termed a closed binary complex or closed complex. The second stage is the unwinding of a short region of DNA within the sequence that is bound to the RNAP. The complex between the polymerase and the partially melted DNA is termed an open binary complex or open complex. The conversion of the closed complex into the open complex leads to the establishment of tight binding between the RNAP and the promoter sequence. For strong promoters, the conversion into an open complex is irreversible. The third stage is the incorporation of two ribonucleotides and the formation of a phosphodiester bond between them. Because the complex at that stage contains an RNA as well as DNA, it is called an initiation ternary complex. Up to seven additional ribonucleotides can be added to the RNA chain without any movement of the polymerase. After the addition of each base, there is a certain probability that the enzyme will release the short (up to nine bases long) RNA chain." #molecularbiology #biology #biotok #transcription #rna #dna

Dr. Xanthine

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Monday 03 June 2024 13:23:14 GMT