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Infertility and pregnancy planning can be tough – selecting a prenatal vitamin shouldn’t be so confusing.
 Patients get stuck between influencers, medical providers, and marketing dollars just trying to select a prenatal vitamin to improve the chances of a healthy outcome for pregnancy.
 One of the most confusing and controversial topics in fertility and miscarriage surround folate, MTHFR, folic acid, methylated folate, and everything in between. 
 Active folate is essential for DNA replication, cellular function, and adequate levels decrease the risk of neural tube birth defects in pregnancy.  Supplementing is important because vitamin B9 found in our diet (leafy vegetables, cereals, etc.) can be inadequate (destabilize with cooking, limited absorption in the intestine).
 Folic acid was designed to meet that need – it is more stable with cooking and is easily absorbed.  We have decades of research showing the need for active folate to decrease risk of birth defects and the effectiveness of folic acid at meeting this need. 
 The confusion surrounds people being told to take a different form of folate supplement called methylated folate, especially if they have a MTHFR genetic variant.
 The MTFHR gene codes for an enzyme that converts dietary folate and folic acid supplements into the active form of folate (L-5MTHF) in the intestine for use in the body. 
 Some claim that people with genetic variants to MTHFR cannot process or are allergic to folic acid but this isn’t entirely true.  
 It is true that methylated folate does not need the conversion to the active form of folate like dietary folate or folic acid do with the enzyme coded for by the MTHFR gene. 
 However, people with an MTHFR genetic variant can be less efficient at converting folic acid to active folate but they aren’t allergic. 
 Many claim methylated folate supplements are more natural (because they don’t need to the conversion) but they are made in a lab just like folic acid supplements. 
 Methylated folate MAY be adequate for preventing neural tube defects but we do not have the decades of information, research, and data to prove that like we do with folic acid. 
 The American College of Obstetricians and Gynecologists recommends a prenatal vitamin with 400mcg of folic acid. 
 One prenatal vitamin to consider is one with both folic acid and methylated folate and like @Bird&Be 
 This is a third party tested prenatal vitamin with 2 forms of folate: 
 400mcg folic acid + 600mcg of methylated folate. 
 
 Resources:
 ACOG.org Nutrition and Pregnancy 
 CDC.gov Folic Acid and MTHFR
 Babiesafter35.com google doc on folic acid and MTHFR
 #infertility #pregnancy #prenatalvitamin #mthfr #folicacid
Infertility and pregnancy planning can be tough – selecting a prenatal vitamin shouldn’t be so confusing. Patients get stuck between influencers, medical providers, and marketing dollars just trying to select a prenatal vitamin to improve the chances of a healthy outcome for pregnancy. One of the most confusing and controversial topics in fertility and miscarriage surround folate, MTHFR, folic acid, methylated folate, and everything in between. Active folate is essential for DNA replication, cellular function, and adequate levels decrease the risk of neural tube birth defects in pregnancy. Supplementing is important because vitamin B9 found in our diet (leafy vegetables, cereals, etc.) can be inadequate (destabilize with cooking, limited absorption in the intestine). Folic acid was designed to meet that need – it is more stable with cooking and is easily absorbed. We have decades of research showing the need for active folate to decrease risk of birth defects and the effectiveness of folic acid at meeting this need. The confusion surrounds people being told to take a different form of folate supplement called methylated folate, especially if they have a MTHFR genetic variant. The MTFHR gene codes for an enzyme that converts dietary folate and folic acid supplements into the active form of folate (L-5MTHF) in the intestine for use in the body. Some claim that people with genetic variants to MTHFR cannot process or are allergic to folic acid but this isn’t entirely true. It is true that methylated folate does not need the conversion to the active form of folate like dietary folate or folic acid do with the enzyme coded for by the MTHFR gene. However, people with an MTHFR genetic variant can be less efficient at converting folic acid to active folate but they aren’t allergic. Many claim methylated folate supplements are more natural (because they don’t need to the conversion) but they are made in a lab just like folic acid supplements. Methylated folate MAY be adequate for preventing neural tube defects but we do not have the decades of information, research, and data to prove that like we do with folic acid. The American College of Obstetricians and Gynecologists recommends a prenatal vitamin with 400mcg of folic acid. One prenatal vitamin to consider is one with both folic acid and methylated folate and like @Bird&Be This is a third party tested prenatal vitamin with 2 forms of folate: 400mcg folic acid + 600mcg of methylated folate. Resources: ACOG.org Nutrition and Pregnancy CDC.gov Folic Acid and MTHFR Babiesafter35.com google doc on folic acid and MTHFR #infertility #pregnancy #prenatalvitamin #mthfr #folicacid

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