@dr.ramez.nairooz: Five medications if taken regularly and for a long time can increase risk of Alzheimer’s disease and/or dementia 1. Allergy medications like diphenhydramine and Benadryl. 2.Antacids proton pump inhibitors like esmoprazole and pantoprazole 3. certain type of antidepressants called tricyclic antidepressants like amitriptyline 4. anticholinergic medications used for treatment of overactive, bladder, and irritable bowel syndrome like hyoscyamine 5. Benzodiazepines like valium and xanax