@nantakie:

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Sunday 29 December 2024 12:19:27 GMT
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I want to share a study being presented as a poster at #SABCS24 by Dr. Savannah Roy and her team (Abstract Number: SESS-2438) looking at the incidence of major adverse cardiovascular events (MACE) (heart attack, stroke arrhythmia or heart failure) in postmenopausal and premenopausal women with hormone receptor-positive breast cancer/HER2 negative undergoing endocrine therapy.  Here are the key points that I go into the video: 📌 The association of cardiovascular events with aromatase inhibitors has been controversial.  📌 This analysis looked at over 26,000 postmenopausal women with HR+/HER2- breast cancer diagnosed at age >65 and premenopausal women diagnosed at age <45 and experiencing premature menopause or undergoing ovarian function suppression. 📌 Patients with HER2-positive breast cancer were excluded to avoid the additional confounder of potential cardiotoxicity from HER2 targeted agents.  ⁉️ What did they find? ⭐️ In postmenopausal women with HR+/HER2- breast cancer, AI treatment was not associated with increased risk of cardiac outcomes compared to tamoxifen.  ⭐️ There was a lower proportion of cardiac events in women with premature menopausal or those undergoing OFS (3.54%) compared to postmenopausal women (28%).  ⭐️ The follow-up was a little under 5 years so we absolutely need longer follow-up but this is very helpful information especially in the short-term.  ⁉️ Let me know your questions on this study or on cardiac toxicity and breast cancer medications in general and will see what I can answer!  #breastcancer #cardiac #heartdisease
I want to share a study being presented as a poster at #SABCS24 by Dr. Savannah Roy and her team (Abstract Number: SESS-2438) looking at the incidence of major adverse cardiovascular events (MACE) (heart attack, stroke arrhythmia or heart failure) in postmenopausal and premenopausal women with hormone receptor-positive breast cancer/HER2 negative undergoing endocrine therapy. Here are the key points that I go into the video: 📌 The association of cardiovascular events with aromatase inhibitors has been controversial. 📌 This analysis looked at over 26,000 postmenopausal women with HR+/HER2- breast cancer diagnosed at age >65 and premenopausal women diagnosed at age <45 and experiencing premature menopause or undergoing ovarian function suppression. 📌 Patients with HER2-positive breast cancer were excluded to avoid the additional confounder of potential cardiotoxicity from HER2 targeted agents. ⁉️ What did they find? ⭐️ In postmenopausal women with HR+/HER2- breast cancer, AI treatment was not associated with increased risk of cardiac outcomes compared to tamoxifen. ⭐️ There was a lower proportion of cardiac events in women with premature menopausal or those undergoing OFS (3.54%) compared to postmenopausal women (28%). ⭐️ The follow-up was a little under 5 years so we absolutely need longer follow-up but this is very helpful information especially in the short-term. ⁉️ Let me know your questions on this study or on cardiac toxicity and breast cancer medications in general and will see what I can answer! #breastcancer #cardiac #heartdisease

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