@revive_with_heather: Replying to @louandherchildren People with a specific variant of the COMT (catechol-O-methyltransferase) gene may experience negative effects when taking quercetin due to the way their bodies process certain compounds. The COMT gene plays a crucial role in the breakdown of neurotransmitters like dopamine, norepinephrine, and epinephrine. It is involved in the methylation process, which adds a methyl group to these neurotransmitters, facilitating their breakdown and removal from the body. When people with low COMT activity take quercetin, a flavonoid commonly found in foods like onions, apples, and tea, they may experience negative side effects. ❗Quercetin has been shown to inhibit the COMT enzyme, which can exacerbate the already slow breakdown of neurotransmitters in those with low COMT activity. This results in a build-up of dopamine and other catecholamines in the brain, which can lead to symptoms like anxiety, agitation, restlessness, irritability, or even feelings of being overwhelmed. 👉🏻This can also be due to increasing histamine levels in the brain which also contribute to anxiety. Other things you can try to support histamine breakdown/ mast cell stabalization - Houttuynia Supreme - PEA - Palmitoylethanolamide - Baking soda in water 🙋🏼‍♀️ if you're looking for more support with histamine intolerance, you can book a consult as I am currently accepting new clients Let me know if you have more questions! This is not medical advice and is for educational purposes only. This information is not meant to treat, diagnose or prevent any medical condition. #histamineintolerance #urticaria #histamineflush #histaminehelp #histaminesensitivity #toxicmoldillness #moldtoxicity #anxietytips #candidaovergrowth #histaminesupport

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_nataliewilson_
Nataliedanielle :
Hello, can you help me in anyway, I don’t know if I have the gene but I was taking quercetin for my rosacea and my skin looks amazing but I have had extreme anxiety, frequent urination, insomnia never had a problem sleeping in the past, heart palpations, tingling in my hands and feet, a lump in my throat. I have stopped taken it but is there anything else I can do to make me feel normal again?
2026-04-09 19:11:45
1
velunamoura
Veluna Moura :
I'm supposed to start quercetin. New fear unlocked.
2025-07-15 20:28:22
4
camberlanae7
Curated by Camber :
I just took a liver support supplement with mine and it helped with that issue.
2025-03-19 16:35:59
24
itstephvalentina
Steph Valentina 🪩 :
Would taking liposomal glutathione with it help this issue theoretically?
2026-08-23 09:35:01
1
beautifullyherr
beautifullyHerr :
Can you take Quercetin at a different time from your iron supplement?
2025-10-01 17:41:52
2
deb56459
Deb :
I have mthfr gene and my histamine levels are high. My Dr doesn't know enough about the gene but said it is probably related?
2026-08-29 14:59:52
2
brittany.edgington
Sonya🔥Earth Angel🔥 :
Sitting here covered in hives, itching, swelling, after I heard your take now I don’t think I want to try quercetin. I got here by trying Neem and yep I’m allergic 😭
2025-02-16 13:27:26
1
le...333
💜 :
what are some negative effects of quercetin that you might notice? it's hard to know what side effects are coming from what
2025-01-14 21:41:51
8
nikyaliezen
Nikya :
How soon do you feel if it’s not for you?
2025-10-22 11:07:53
1
jacquee_powpow
jacquee_powpow :
I'm so happy i found this. i was having what i think is seasonal allergies. my Anxiety went THROUGH THE ROUGH! My digestion went funky. i dont typically have sleeping issues- had insomnia. I'm also anemic and taking sups for that and felt like garbage while taking quercetin. UGH! I had no idea. thank you!!
2026-03-06 05:19:46
2
russianmeowfia
Ольга ♡ :
can I take it if I have fast COMT?
2025-01-14 22:46:57
1
themotherofthor
themotherofthor :
I have MTHFR and SLOW COMT and I’m so confused as to the best things to do
2025-08-22 21:27:07
12
bray21
Sam :
Will beef liver capsules help with this?
2025-04-24 14:01:35
0
anniesandy249
anniesandy249 :
I have issues with MTHFR and COMT. When I take quercetin I just don’t notice any benefits.
2025-01-03 04:13:16
6
sahm3_blb
Brittney|Wife|Mama|🌻 :
Could this help with rashes 😭 mine has been chronic on my face and neck and chest. No cream has helped and they’ve given me so many.
2026-03-25 17:04:35
2
heritagerootshealing
Heritage Roots Farmacy :
Can it give you diarrhea? Every time I take Hist Reset with it I end up by the toilet.
2025-06-03 22:25:18
1
cameron53168
Cameron Mims :
makes sense. I have very slow motility so my liver is sluggish and quercetin and antihistamine complexes with it make me queasy and headache-y
2025-11-05 23:13:05
5
kaitlin177
kaitlin :
My naturopath recommended DAO short term for me bc I have met/met COMT
2025-01-04 16:49:04
5
carolinemccormack23
Caroline🫶🏼 :
Does this go hand in hand with MTHFR? Reccomend glutathione?
2025-01-05 19:57:45
10
blessedlittlepaw
blessedlittlepaw :
Have you ever been very restricted? All I can eat is beef and quinoa with protein. I don’t even want to share my cholesterol because of the beef. OOF! I wish I could add more proteins!
2025-02-01 00:59:09
2
naifqa34
naifqa34 :
can I take it if I have gout instead of allopurinol?
2025-07-13 13:03:17
1
jillkottmeier
Jill Kottmeier :
How do you test for the gene?
2025-01-05 19:27:09
1
jess_slone93
Jess 🦉 :
I’ve taken quercetin for the past couple days and could not figure out what was wrong and why I started randomly breaking out in painful red burning hives all over my body.. welp, makes sense.
2025-04-26 14:43:27
1
user4876142470132
Doodle Mama :
Would a quercetin iv bypass this issue?
2025-08-12 01:30:44
2
stephaniecayson25
stephaniecayson25 :
I need your hair routine/ product details. Beautiful 💕
2025-11-09 07:03:58
1
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