@moreplates: Do You Need To Cycle Off Of Creatine? No, you do not need to cycle off creatine. Your body does not get used to it, and long-term use has shown to be safe in healthy adults. In a randomized clinical trial assessing the effect of creatine monohydrate on clinical progression in patients with Parkinson’s disease, participants were randomized to placebo or 10 grams creatine monohydrate per day (the typical recommended dose for most people is 3-5 g per day), for a minimum of 5 years. Long-term creatine use did not appear to adversely affect renal function or body mass index, and the 10 grams per day dose was determined to be generally well tolerated.