@aishahusain929:

Aisha Haji
Aisha Haji
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Wednesday 16 July 2025 17:56:33 GMT
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I recently read this really intriguing paper published in the journal Nature in 2025 titled:
I recently read this really intriguing paper published in the journal Nature in 2025 titled: "Intrinsic electrical activity drives small-cell lung cancer progression". The paper explores a phenomenon that connects cancer biology with neuroscience. SCLC is a mixture of 2 cell types: Neuroendocrine (NE) cells and Non-NE cells. NE cells are derived from a rare cell type that lines the epithelial of the lung called the Pulmonary neuroendocrine cells (PNECs). These cells normally regulate how the lungs sense oxygen level and communicate with the brain. So naturally, the authors looked at NE cells and noticed that they spontaneously have these electrical signals that spread from one NE cell to another, much like between neurons. Turns out that this electrical signal helps NE cells grow and metastasize better! Only NE cells have this electrical communication, and it can be activated by a direct electrical stimulation! And much like how neurons rely on astrocytes for nutritional support, NE cells rely on Non-NE cells for the same thing, Lactate! Generating these electrical signals demand a lot of energy, and so Non-NE cells provide Lactate as the source of energy for NE cells. Indeed, when culture the two types together, the electrical signal between NE cells increase! I thought this is a very intriguing paper that draws a parallel comparison to how nerve cells communicate. How NE cells use electrical signal to help them proliferate and spread is still unclear. Do neurons have a direct impact on NE cells since they are electrically communicative too? Many interesting questions remain. #science #cancer #biology #fyp #cool

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