@biolayne: I am VERY Skeptical About Collagen… This might be an unpopular opinion, but IMO collagen supplementation has not been shown to have clear benefits A new meta-analysis (PMID: 40324552) looked at this skin elasticity and aging & determined there was a positive effect of collagen supplementation on skin aging… BUT The researchers did a sub-analysis where they separated the results into those studies sponsored by companies that sell collagen products vs. those studies that were not sponsored by those companies. They showed that the studies funded by companies selling collagen had positive effects but the studies that were funded independently did NOT show significant beneficial effects indicating that there may have been bias influencing these results Now there was still a small positive effect of collagen on these outcomes but I am unconvinced that this is not simply an effect of increased protein overall In this study (PMID: 40523226), healthy adults were given 30g of hydrolyzed collagen or 30g of matched free amino acids post workout & the researchers examined rates of muscle protein synthesis (MPS), connective tissue protein synthesis (CPS), & skin protein synthesis (SPS) Spoiler alert: collagen supplementation FAILED to increase MPS, CPS, or SPS This is not surprising to me since other studies have demonstrated that collagen does not increase CPS compared to regular ol’ whey protein (PMIDs: 37202878 & 39086044). I am not sold on collagen at all as it has a horrible amino acid profile (way worse than any plant protein) & even high doses of it do not increase MPS or CPS (PMID: 40523226). IMO it’s a waste of $ & you can get as good or better results by using whey protein & wearing sunscreen If you love research breakdowns like this make sure you subscribe to my research review, REPS. Each month we break down 5 studies in a simple, easy to understand way without unnecessary scientific mambo jumbo. We tell you what they tested, why they tested it, what they found, & what it means for YOU. At less than the price of a weekly coffee, it’s the best way to level up your brain & body gains. Hit the link in my bio to subscribe today

Layne Norton, PhD

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Wednesday 27 August 2025 15:25:55 GMT