@jessicaryniecmd: Does transferring embryos on day 3 (cleavage stage) or day 5 (blastocyst stage) give better outcomes? Here’s what studies show: 🔹 Day 5 (blastocyst) transfer Many randomized trials + cohort studies show higher implantation + clinical pregnancy rates compared to day 3 — especially in patients with multiple embryos available Blastocyst culture helps labs select embryos with the highest developmental potential Pushing to blast facilitates single embryo transfer (SET), which reduces the risk of twins or higher-order multiples 🔹 Day 3 vs Day 5 live birth rates When adjusting for age + embryo quality, differences in live birth rates are smaller, some studies show no significant difference when equal numbers of embryos are transferred 🔷️ THE BOTTOM LINE Day 5 transfer is often the best option when there are multiple high-quality embryos, but day 3 transfer remains valid in patients with fewer embryos or certain clinical situations. The decision should be individualized based on age, ovarian reserve, embryo quality, and lab conditions . . . . . #ivf #ivfsuccess #embryotransfer #embryotransfersuccess #infertility #infertilitycommunity #embryologist

Dr Jessica Ryniec fertility MD

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Region: US

Wednesday 27 August 2025 19:16:05 GMT