@drsermedmezher: Did Scientists Just Cure Aging? #breakthrough Source: PMID: 40516525 Scientists in China have recently used specially engineered stem‐like cells to roll back multiple aging markers in elderly macaques, offering one of the most comprehensive primate rejuvenation studies so far. The cells, called senescence-resistant mesenchymal progenitor cells (SRCs), are designed to resist both aging stress and senescence (i.e. becoming old and less functional). Researchers reprogrammed human genetic pathways associated with longevity to make these SRCs less prone to damage, less likely to turn into tumors, and better able to survive in aged bodily environments. In the experiment, macaques roughly equivalent to humans in their 60s-70s were given intravenous injections of these SRCs biweekly for about 44 weeks. The outcomes were striking: improved cognitive performance; reductions in tissue degeneration (such as in brain, ovaries, and bones); less fibrosis and lipid buildup; better hormone regulation and tissue regeneration; decreased markers of inflammation; fewer senescent cells; and at a molecular level, many tissues began to express genes more like younger animals. Biological-age clocks (using gene expression and other biomarkers) estimated that in some cell/tissue types the “age” was reversed by about five to seven years. #aging #Science #longevity

Dr Sermed Mezher MBChB MRes

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Sunday 21 September 2025 17:47:24 GMT