@dr.amybkillen: How do the doses of hormone therapy affect endometrial thickness (and endometrial cancer risk)? 🤔 This new study by Glynne and @menopause_doctor had some surprising findings as discussed in the video. My only wish is that they'd looked at the estradiol to progesterone ratios vs endometrial thickness and not just hormone doses and estradiol serum levels. 🥳 I did a deep dive on this study and reviewed some key info about preventing endometrial cancer in this week's Substack so check it out. ✅ dramybkillen.substack.com 🎉 P.S. Do you want to learn more about how GLP-1 medications (ex: Ozempic) affect cancer risk in women? If so, let me know below! 👇

Dr. Amy Killen MD
Dr. Amy Killen MD
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Thursday 02 October 2025 17:43:21 GMT
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mounjarho
withaney :
So if I’m post-menopausal, should I be maxed out on the estradiol patch?
2025-10-02 20:10:23
0
lakotawin
Win :
I had to stop the lowest dose of progesterone and you can take. It was making me crazy. Any suggestions?
2025-10-08 09:21:20
1
thisisme7053
ThisIsMe :
Could you elaborate on why getting the ultrasound?
2025-10-03 03:08:52
1
appleorangebanan
Apple :
Good information, thank you
2025-10-04 16:53:22
1
daraanndauterivefleming
daraanndauterivefleming :
Great info.
2025-10-02 19:05:38
1
yeye.2024
LKW :
7x!
2025-10-02 18:26:41
1
fifilefeef
Fiona :
@neexx22 does this apply to you?
2026-01-13 21:49:17
1
applejacks_86
applejacks_86 :
@Dr. Amy Killen MD To further add to your post and make sense of the study …The new study shows that blood estrogen levels from patches vary a lot between women, so the idea that more estrogen always means needing more progesterone isn’t always true. Women with a uterus still need progesterone to protect against estrogen risks, but the right amount depends on how their body responds, not just estrogen dose. This means hormone therapy should be personalized and guided by medical advice, not fixed rules.
2025-10-03 02:36:42
4
ld9876543
user8333219545855 :
😂😂😂
2025-10-24 02:45:02
0
wideopenspaces44
user1650100692112 :
❤❤❤
2025-11-04 16:41:03
0
purple.lara
Lara 🇨🇦 :
Vaginally, rectaly, orally, progesterone, progestin, Mirena. Tried them all. It wouldn’t hurt you to believe women’s lived experiences instead of writing novels about how they’re wrong about the things they’ve literally personally experienced. Stop talking to me thanks.
2025-10-05 03:04:34
0
e.schulten20
Elizabeth Schulten :
Testosterone!
2025-10-03 08:19:39
0
mariahsarey
Mariahsarey :
This study actually shows so much more than just estradiol and progesterone ratio fallacy. 1 in 4 women on maximum licenced doses still have low estradiol (under 50pgml) and 1 in 6 on high off label doses had low estradiol. This symptoms only, transdermal only basic .025 .05 & .1 needs to be discontinued. It is not serving women well at all. There’s no mention of FSH which is a significant marker of adequate individual estradiol dose suppression between 5-10. Ultrasounds to assess lining at least yearly needs to be part of hrt care as commonly as mammograms and OBGYNs need to stop running completely unessasary biopsies on women causing fear and significant trauma because of the slightest bit of spotting post on hrt. I can’t tell you how many women have thin linings slight spotting and are told they must have a biopsy it could be cancer! It’s terribly painful for many and they’re so traumatized they want to stop their hrt and suffer with the devil they know. Women need higher doses, women need diversity of delivery for all their sex hormones (self injections are awesome) labs need to be assessed at least yearly and more frequently as the doses are being dialed in, shbg and fsh need to be included in serum testing and providers need significant training on how to order and interpret sex hormone serum labs. Hormones are fluctuating is a cop out. End rant 😬
2025-10-02 23:32:49
11
gracengrit48
Grace&Grit :
and bleeds aren't always endometrial. talk about vaginal tissue thinning & capillary response to vaginal estrogen
2025-10-04 16:10:52
1
jgreorge
j.a.i.m.i.e :
I love progesterone and want to take 300 instead of 200. I’m on 3 pumps of Estrogel
2025-10-10 07:19:23
3
dr.gina_vyskocil
Dr.Gina_Vyskocil :
This is very helpful. Taking list of questions to gyn visit upcoming
2025-11-08 20:00:34
1
fifilefeef
Fiona :
@Jen’s Menopause Tips + Hacks for your helpful gyno 😂
2025-11-01 15:48:27
1
wilsonerviliayahoo.com
Timmy15 :
What if you don’t have a uterus? Should you take progesterone
2025-10-03 05:26:16
1
cracanada
Josie :
cant adford glp 1. i guess i will get cancer
2025-11-01 04:58:29
0
nixwhittaker
Nix Whittaker 🇳🇿 :
can you talk about EDS. as that's what causes my issues but my Dr is clueless
2025-11-17 08:31:01
0
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