@dr.amybkillen: Is it too late to start HRT?? - Part 1: Is it safe? ❓ ⏳ We recommend you start HRT as soon as possible after menopause onset and many guidelines recommend you do so within ten years. But, because of the misinformation from the WHI, many women missed that "critical window" and are considering starting HRT later. 😏 Although the WHI saw a SLIGHT increase in heart attacks and strokes in Late Starters put on Premarin and MPA (we're talking an extra 8 or so per 10,000) we've not seen the same risks with estradiol and progesterone. 💪 Premarin strongly activates matrix metalliproteinase-9, which may contribute to clot rupture. And MPA is an inflammatory 🤮 type of synthetic Progestin so I wouldn't use those in Late Starters. But, transdermal Estradiol + Progesterone have great safety profiles, even in Late Starters. 💃 Stay tuned for part 2: "Is it Effective?" As always...Like, Share and Follow. 🙏 #menopause #hrt #hormonereplacementtherapy #hormonbalance #perimenopausehealth #perimenopause #menopause #womenshealth

Dr. Amy Killen MD

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Friday 14 November 2025 21:03:48 GMT