@ambreen.rauf: Stress creates rapid molecular changes inside the amygdala, the brain region that processes fear, alertness and emotional reactions. When the body senses a stressful event, nerve pathways send fast signals to the amygdala. This activates cells that release chemical messengers such as glutamate. Glutamate makes nearby neurons fire more easily, raising the overall activity level of the region. At the same time, stress hormones released from the adrenal glands begin to reach the brain through the bloodstream. These hormones attach to receptors on amygdala cells and increase their sensitivity. Inside the neurons, the rise in stress hormones changes how certain genes are switched on or off. These shifts affect the production of proteins that help neurons form new connections. Some connections become stronger, while others weaken. This reshaping of synapses makes the amygdala more reactive to future stress. Calcium levels inside the cells also rise during this process. High calcium influences many internal pathways and can amplify the activity of the neuron. If stress continues for a long time, these molecular signals make the amygdala remain in a heightened state. The network becomes more excitable and more responsive to minor triggers. This early molecular shift forms the foundation for stronger emotional reactions during ongoing stress. #stress #amygdala

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Thursday 04 December 2025 12:16:03 GMT