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MinhThienStore21
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Friday 02 January 2026 05:08:04 GMT
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POV: Their Face Looks Like This. Sources- PMID 31847045 landgravestudios on TT A migraine aura is primarily triggered by a neuroelectrical phenomenon known as cortical spreading depression (CSD). This process begins as a localized, intense wave of hyperactive cellular depolarization, where nerve cells fire rapidly all at once, typically starting in the visual cortex at the back of the brain. Immediately following this hyperactive surge, a prolonged wave of profound neural suppression sweeps slowly across the brain's surface at a rate of roughly three millimeters per minute. As this slow-moving wave of altered electrical activity suppresses normal brain function, it directly manifests as the classic, evolving sensory distortions of an aura, such as expanding blind spots or shimmering zigzag lines in a patient's field of vision. While this electrical wave rolls across the cortex, it simultaneously causes dramatic, matching fluctuations in regional blood flow that compound the neurological disruption. The initial hyperactive wave triggers a brief expansion of local blood vessels, which is instantly followed by a prolonged narrowing of those vessels as the wave of neural suppression takes over. This temporary constriction significantly reduces blood flow to the active areas of the cortex, further depriving the affected nerve cells of normal oxygen levels and intensifying the sensory symptoms. Ultimately, this entire cortical disturbance irritates the nearby trigeminal nerve pathways, releasing inflammatory chemicals that set the stage for the severe, throbbing headache that typically follows. #migraine #vision #aura
POV: Their Face Looks Like This. Sources- PMID 31847045 landgravestudios on TT A migraine aura is primarily triggered by a neuroelectrical phenomenon known as cortical spreading depression (CSD). This process begins as a localized, intense wave of hyperactive cellular depolarization, where nerve cells fire rapidly all at once, typically starting in the visual cortex at the back of the brain. Immediately following this hyperactive surge, a prolonged wave of profound neural suppression sweeps slowly across the brain's surface at a rate of roughly three millimeters per minute. As this slow-moving wave of altered electrical activity suppresses normal brain function, it directly manifests as the classic, evolving sensory distortions of an aura, such as expanding blind spots or shimmering zigzag lines in a patient's field of vision. While this electrical wave rolls across the cortex, it simultaneously causes dramatic, matching fluctuations in regional blood flow that compound the neurological disruption. The initial hyperactive wave triggers a brief expansion of local blood vessels, which is instantly followed by a prolonged narrowing of those vessels as the wave of neural suppression takes over. This temporary constriction significantly reduces blood flow to the active areas of the cortex, further depriving the affected nerve cells of normal oxygen levels and intensifying the sensory symptoms. Ultimately, this entire cortical disturbance irritates the nearby trigeminal nerve pathways, releasing inflammatory chemicals that set the stage for the severe, throbbing headache that typically follows. #migraine #vision #aura

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