cali man x p53. what's your favorite tumor suppressor gene? sources: nature video p53: Guardian of the Genome, Maja Divjak The Role of p53 in Cancer, WEHImovies p53 Tumour Suppressor (2016) by Etsuko Uno, Centenary Institute p53 bisensor being activated following DNA damage, Animated biology With arpan p53 in cell cycle regulation | p53 and cancer | p53 tumor suppressor, Neural Academy p53 Tumour Suppressor and MDM2, PlayStation Europe Destiny 2: Beyond Light | Launch Trailer | PS4, Timeflows orchid timelapse article: Joyce C, Rayi A, Kasi A. Tumor-Suppressor Genes. [Updated 2023 Aug 28]. In: StatPearls "The TP53 tumor suppressor gene is also known as the “guardian of the genome” as it serves to monitor for cellular stress like anoxia, identify DNA damage, or inappropriate signaling by mutated oncoproteins.The TP53 gene encodes for the p53 protein, which controls the expression of proteins and their activity in cell cycle arrest, cellular senescence, DNA repair, and apoptosis. Loss of p53 can cause continued cell replication despite DNA damage. The DNA damage is perceived by complexes comprising kinases of the ATM/ATR family. These kinases phosphorylate p53, releasing it from inhibitors such as MDM2. The active p53 upregulated the expressions of important proteins like cyclin-dependent kinase inhibitor p21, which causes G1-S checkpoint arrest of the cell cycle. In instances where the DNA damage is not repairable, p53 induces events like activating the BAX gene, which encodes a pro-apoptotic protein that finally lead to cellular apoptosis or senescence. It also works to inhibit the BCL2 anti-apoptotic gene and stimulates the release of cytochrome c from the mitochondria. Cytochrome c activates caspases within the cell. Most of the cancers demonstrate a biallelic loss-of-function mutation in TP53. Uncommon patients with Li-Fraumeni syndrome have a very high incidence of a wide variety of cancers." #genetics #p53 #caliman #apbio #cancerawareness - @chemedits