@drsermedmezher: POV: You Have a Hot Flash in the Cold. Sources- PMID 31001050 breaking90fitness on TT Hot flashes are primarily driven by the fluctuating levels of oestrogen that occur during menopause, which disrupts the body’s internal thermostat located in the hypothalamus. When oestrogen levels drop, this region of the brain becomes hypersensitive to even slight changes in body temperature, triggering an unnecessary "cooling" response. This results in the sudden dilation of blood vessels and a rush of heat known as a vasomotor symptom. While Hormone Replacement Therapy (HRT) is a common treatment, it is not suitable for everyone, particularly those with a history of certain cancers or blood clots. Fortunately, there are several effective non-hormonal medical options available that can help recalibrate the brain's temperature control system. Medications like clonidine, originally used for high blood pressure, can reduce the frequency of flashes by stabilizing the way blood vessels react to brain signals. Similarly, certain SSRIs or SNRIs, which are typically used for mood, have been found to significantly dampen the intensity of hot flashes by altering the neurochemicals that communicate with the hypothalamus. Newer options like fezolinetant specifically block the brain receptors responsible for triggering heat surges without using hormones at all. Because these treatments require careful matching to your personal health history, it is essential to speak with a doctor to find the most effective path for your body. #menopause #hotflash #women

Dr Sermed Mezher MBChB MRes

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Thursday 29 January 2026 21:14:23 GMT