@doctor.asky: Amyloid protein slowly builds up inside brain tissue during Alzheimer development. Alzheimer related amyloid buildup begins when certain proteins in the brain start behaving in an unusual way. One of these proteins is called amyloid which normally exists in a harmless form. Over time small pieces of this protein can break off and stick together. These pieces begin forming tiny clusters that gradually grow into larger deposits. These deposits settle between brain cells where they interfere with normal communication. As the amyloid clusters become bigger they create stress for the surrounding brain tissue. Nerve cells depend on smooth communication to process memories, thoughts, and daily functions. When amyloid buildup becomes dense the signals between these cells slow down and eventually become disrupted. This slowing down is one of the early changes seen in Alzheimer disease and it happens long before symptoms become obvious to the person. Over time the brain tries to react to this buildup but the response can lead to swelling and further damage. The affected areas begin to lose connections and nerve cells start to weaken. When enough cells are damaged the brain struggles to form or store memories and thinking becomes harder. This ongoing change is one of the key processes that drives the progression of Alzheimer disease. PMID: 20061647
