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@shanisukhera1122:

burewala sa hou yrr♥️
burewala sa hou yrr♥️
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Monday 09 February 2026 18:28:13 GMT
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sufyan...06
Vampire.student04 :
🥰🥰🥰
2026-02-23 19:34:24
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aliraza75g0
Ali Raza goriya :
🥰🥰🥰
2026-02-18 08:07:50
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akelilardke
سب بے وفا ہے صنم جی :
❤❤❤
2026-02-10 09:35:16
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sufyan...06
Vampire.student04 :
♥️♥️♥️
2026-02-23 19:34:28
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Brain Training Improvement Requires New Myelin This study investigates the requirement for oligodendrocyte (OL) production in non-motor cognition, specifically spatial working memory in adult mice. Using T-maze and 8-arm radial maze tasks, genetic blockade of OL differentiation significantly impaired training-induced performance improvements (control mice achieved ~82% success vs Myrf-cKO ~67% in T-maze; ~31% perfect trials vs ~16% in RAM). Maze training stimulated robust OLP proliferation (~4-fold increase) and new OL generation in key brain regions like the corpus callosum and mPFC. Crucially, individual performance strongly correlated with OLP proliferation (R2=0.84 CC) and new OLs (R2=0.61 CC). Myelination was enhanced, evidenced by a significant ~25% increase in axonal node/paranode structures (6.1 vs 4.8/mm² CC). No positive correlation was found with bulk neuronal activity (c-Fos). Findings demonstrate new OLs are essential for working memory training outcomes. Shimizu, T., Nayar, S. G., Swire, M., Jiang, Y., Grist, M., Kaller, M., Sampaio Baptista, C., Bannerman, D. M., Johansen-Berg, H., Ogasawara, K., Tohyama, K., Li, H., & Richardson, W. D. (2023). Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice. *Nature Communications*, *14*(1), 6499. https://doi.org/10.1038/s41467-023-42293-4 #brain #neuroscience #cognition #myelin
Brain Training Improvement Requires New Myelin This study investigates the requirement for oligodendrocyte (OL) production in non-motor cognition, specifically spatial working memory in adult mice. Using T-maze and 8-arm radial maze tasks, genetic blockade of OL differentiation significantly impaired training-induced performance improvements (control mice achieved ~82% success vs Myrf-cKO ~67% in T-maze; ~31% perfect trials vs ~16% in RAM). Maze training stimulated robust OLP proliferation (~4-fold increase) and new OL generation in key brain regions like the corpus callosum and mPFC. Crucially, individual performance strongly correlated with OLP proliferation (R2=0.84 CC) and new OLs (R2=0.61 CC). Myelination was enhanced, evidenced by a significant ~25% increase in axonal node/paranode structures (6.1 vs 4.8/mm² CC). No positive correlation was found with bulk neuronal activity (c-Fos). Findings demonstrate new OLs are essential for working memory training outcomes. Shimizu, T., Nayar, S. G., Swire, M., Jiang, Y., Grist, M., Kaller, M., Sampaio Baptista, C., Bannerman, D. M., Johansen-Berg, H., Ogasawara, K., Tohyama, K., Li, H., & Richardson, W. D. (2023). Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice. *Nature Communications*, *14*(1), 6499. https://doi.org/10.1038/s41467-023-42293-4 #brain #neuroscience #cognition #myelin

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