@dansfera: This regulatory loophole is wild! For years, the FDA only required proof of **drug safety**, thanks to a 1972 amendment. Efficacy? That crucial step was totally skipped. 🤯 Imagine decades of prescriptions for medications that were confirmed *safe*, but no one knew if they actually worked! The agency had to step in during the 90s, offering exclusivity incentives just to get companies to finally prove effectiveness on these legacy drugs. A fascinating peek into how pharmaceutical rules actually evolved. #FDA #DrugHistory #PharmaFacts #MedicalHistory #Regulation