@drsermedmezher: New Creatine Dose Research? Doctor Explains. Sources- Diary of a CEO Podcast PMID 40395689 Creatine monohydrate is one of the most thoroughly researched supplements in existence, primarily known for its ability to increase the body's stores of phosphocreatine. This molecule is essential for the rapid regeneration of adenosine triphosphate (ATP), the primary energy currency used by cells during high-intensity physical tasks and demanding cognitive processes. For the general population, the standard recommendation is a daily dose of 5g. This "robust" dose has been shown to effectively saturate muscle tissues over time, leading to improved strength, power output, and even modest gains in working memory and mental fatigue resistance, especially in individuals who may be slightly deficient, such as vegetarians. +2 While 5g remains the gold standard for most, an emerging frontier of medical research is investigating significantly higher doses for specific neurological conditions. In patient groups dealing with neurodegenerative diseases like Alzheimer's, researchers have explored doses as high as 20g per day. The rationale behind this aggressive supplementation is that the brain may require a much higher concentration of creatine to overcome the "energetic crisis" and mitochondrial dysfunction characteristic of the disease. It is important to note that while these high-dose studies are promising, they are still in the early, exploratory stages. For the average person looking for a physical or mental edge, jumping to 20g is generally unnecessary and may lead to digestive discomfort, as the 5g daily dose is far better supported by long-term safety data and clinical efficacy. #creatine #supplements #health

Dr Sermed Mezher MBChB MRes

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Friday 13 February 2026 21:54:56 GMT