@jagannathanneurosurgery: After years in neurosurgery, here’s my take. Ozempic, Wegovy, and Mounjaro (GLP-1–based medications) are not cosmetic drugs. They target metabolic disease — and metabolic disease directly impacts the brain. What high-quality trials show: • SELECT (NEJM, 2023): Semaglutide reduced major cardiovascular events in overweight/obese adults without diabetes. • SUSTAIN-6 (NEJM, 2016): Semaglutide reduced stroke risk in patients with type 2 diabetes. • SURPASS program (2021–2023): Tirzepatide produced substantial weight loss and improved glycemic control. Why this matters in neurosurgery: Obesity, insulin resistance, hypertension, and systemic inflammation increase the risk of ischemic stroke, vascular cognitive decline, and poorer surgical outcomes. These medications are powerful tools, but they are not appropriate for everyone and they carry potential risks. Decisions about starting them should always be made in consultation with your physician, based on your individual medical history #fyp #neurosurgeon #AskDrJay #trending #doctor

Jay Jagannathan, MD
Jay Jagannathan, MD
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Sunday 22 February 2026 21:12:32 GMT
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emergmd
EmergMD :
As an emergency physician, let me tell you about glioblastoma surgery. Oh… that’s not my field. Maybe I should stay in my lane.
2026-02-23 16:17:46
821
hcarrier0
HollyJLouie :
Husband has almost lost all vision due to monjouro.
2026-02-23 10:55:18
25
dr.richard006
Dr. Richard Walker :
I'm a neurosurgeon doctor also
2026-10-23 00:47:11
0
jj.babe11
jj.babe11 :
Don’t forget the huge benefit of us women with PCOS. I have never felt more normal in my entire life than I do now being on Tirzepatide
2026-02-23 20:38:50
1628
kris10ishere
kris10ishere :
They’ve been a lifesaver for perimenopause. Joint pain and inflammation gone.
2026-02-23 21:13:24
241
pattisaidso
PattiSaidSo :
My Texas teacher insurance would rather pay for all my obesity-related issues and depression than just help me lose weight and improve my mental health. It sucks.
2026-02-23 23:21:12
250
stephleskovansky
STEPH❤️❤️ :
I think it’s crazy that everyone is taking it!!
2026-02-23 20:42:10
179
jttdale
Jeri :
As a three month user of a glp1, I lost my gallbladder and now have gastroperisis. DO YOUR RESEARCH! 1 in 200 will develop gastroperisis!
2026-02-23 17:15:58
40
ireneliz_65
Ireneliz_65 :
My rheumatologist said she heavily researched glp1s for herself and decided against them. She’s an extremely smart lady.
2026-02-23 21:57:16
10
flowerswithpowers32
Flowerswithpowers :
Been on it 3 years. Feel normal and food noise is gone. Down 47 lbs. you do develop a tolerable though
2026-02-24 07:06:35
22
mrsswagganair
MrsSwagganair💥BlaxxGang💥 :
I've been able to stay on .25 of Ozempic for 3 months and its working for me, even though everyone said that dose does nothing. Blood sugars normal again, eating better, less arthritic pain, losing about 2 lbs a week ( which im ok with). I think alot of the bad effects are ppl not using it responsibly. Moving up too fast, using more than they need to, not eating etc. I will stay at .25 as long as its doing something for me.
2026-02-25 14:44:03
5
us.virginia2
us.virginia2 :
I would not use any of them!
2026-02-24 00:37:00
25
angetubbs
Mama Angie 🦩🦋🐬 Gen ❌ 1970 :
My hair falling out after just few injections and then my stomach paralyzed. Bad bad
2026-02-24 02:02:44
23
jessicahalfast
jessicahalfast :
Glp1 warrior for 6 years. Saved my life. No more bo meds, thyroid meds and haven't had a drop of alcohol since 2022
2026-02-23 22:19:12
262
ashamoore422
Ashley/SN 🩺👩🏽‍⚕️ :
My family medicine doctor told me straight up NO and I trust her opinion.
2026-02-23 21:43:44
56
hugteri2
Hugteri :
Lost sight in my eye from a blood clot after taking mounjaro for 4 months
2026-02-23 21:44:07
9
tammyharrington77
Tammy Harrington :
I’m super nervous s about the muscle loss.
2026-02-24 03:40:27
5
familyadventuresohmy
CandieLynn :
I’m dying for someone to do research on their affects on auto immune disorders such as celiac disease or MS.
2026-02-24 03:52:27
61
champaignemami1
xzadra :
A glp1 disrupted my whole nervous system. Started to get panic attacks, heart palpitations/racing heart, dizziness. & yes I ate. Hydrated myself! & I got it from my doctor. I regret ever taking it!
2026-02-26 20:17:00
5
carolinapastrana8
Carolina Pastrana :
Wegovy gave me pancreatitis after only being 3 weeks on it.
2026-02-24 01:01:11
10
juhnene
Janine :
I have gastroparesis and I wouldnt wish it on anyone
2026-02-24 02:21:30
118
girlchangesmom
Ariyaskeeperandsissy :
So many lose gallbladders too
2026-02-24 02:12:57
14
i_got_the_music_in_me
I got the Music in me :
I am insulin resistant,had an emegency craniotomy after a brain bleed caused by cavernoma and venous malformtion and it was my neurosurgeon that suggested a GLP1. Minus 110lbs, weight training daily and yoga. I am like a new person.
2026-02-23 10:22:41
232
kaitlynbbb3
Kaitlyn B :
I’ve been on the shot for 2 weeks, my hands have been completely numb for 6 days now.
2026-02-23 15:42:14
20
anitamariecasarez1995
Anita Casarez :
I have been on ozempic since 2018.
2026-02-23 16:11:10
25
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