@williamkotc: In biology, ions are charged particles, which means they cannot pass through the cell membrane on their own because the membrane is made of a hydrophobic lipid layer that repels anything charged or polar. If an ion tries to go straight through, it will not work no matter how many times it tries. The only way ions can move across the membrane is through special proteins like ion channels or pumps that are built specifically to let them pass. In the video, the declined attempts represent trying to cross the membrane the wrong way, while the approved attempt represents using the correct method that actually works. The idea is that sometimes the problem is not effort, it is the approach, and using the right pathway makes all the difference #kingofthecurve #kotc #stem #biology