@theholdernessfamily: Penn shared a personal update on this week’s podcast about his journey to fight Alzheimer’s.

The Holderness Family
The Holderness Family
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Region: US
Thursday 09 April 2026 16:57:09 GMT
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michellelong245
Shelly 🌸 :
It does amazing things for ADHD. I won’t ever get off of it for that reason alone.
2026-04-09 20:57:41
1621
brandyhailey
Brandy Hailey :
I also have the APOE4 gene. My paternal grandmother had Alzheimer’s and my father (73) is having memory issues. This is a big concern for me. I have been on Zepbound for weight loss for 1.5 years now. I am down 90 pounds, but I also hope this will help me long term to keep my memory and not develop Alzheimer’s.
2026-04-10 14:43:16
36
8515healthandfitness
8515HealthAndFitness :
I am a double APOE4 carrier and I’ve been on tirzepatide for this exact reason for 2 years.
2026-04-13 03:06:48
42
drjolenebrighten
Dr. Jolene Brighten :
They’re showing a lot of promise for many conditions, including heart disease, which the APOE is always associated with
2026-04-09 21:56:08
942
kimberleyscott945
Kimberley 🇨🇦 :
I have MS and am taking it for the anti inflammatory results
2026-04-09 21:58:26
607
.peggylee
Peggy :
I take it for Autoimmune disease inflammation and hormone regulation.
2026-04-10 00:14:01
383
dee_dee797798
dee_dee797798 :
I’ve been on trizepitde for 5 weeks, the amount of inflammation that has left my body is insane. I do not think I will ever get off this medicine
2026-04-11 15:17:31
75
mommaball91
maggieB :
Taking it stopped my heavy drinking. The weight loss was a happy byproduct.
2026-04-10 03:59:52
306
maharahman102
maha rahman :
That must’ve been hard to hear 😩 Alzheimer’s changes everything… and it made me reflect on my own memory struggles during menopause… forgetting things, losing focus and feeling mentally foggy. It scared me. I thought something was wrong. Nothing I tried helped. Then someone in a hormone group mentioned Menopause Transition Playbook (written by Lisa Grant). Things changed… 28 lbs gone and I finally feel mentally sharp again. Honestly feels like hidden info.
2026-04-12 18:53:01
493
charmingcheek
CharmingCheek :
Crossing my fingers for everyone who needs this help! I’m on it for kidney function and autoimmune issues - my GFR went from 77 (stage 2 chronic kidney disease) to 93 (healthy)!
2026-04-09 17:21:37
84
dalenestephens
Dalene Stephens 💙 :
It’s unfortunate that allllll this science and studies coming out, that I still had a doctor tell me three weeks ago that GLPs are not going to help me with weight loss and i shouldn’t want it anyway because it would make my face look weird. This is AMAZING!!! The medical community should be excited- assuming they went into medicine for the right reasons- to actually HELP people! Thank you for sharing your journey!!!! Adding it to my information bank!
2026-04-10 18:59:21
40
kakijeff1
kakijeff1 :
My daughter had a stroke at 42. Her dr recommended glp1 for stroke prevention. Many uses for this drug.
2026-04-09 23:23:46
85
tracietracietraci
TracieTracieTracie :
I’ve had no desire for alcohol and my arthritis inflammation went way down
2026-04-10 02:18:56
61
annvothrudy
Ann Voth Rudy :
I started for weight loss. I stayed on for all the benefits.
2026-04-10 17:45:22
87
kaytell13
Kay C :
I've been on GLP1 for going on 4 years for inflammation & weight loss. 80lbs down & holding. It's the best thing I've ever done for myself.
2026-04-10 01:30:37
28
boymomma473
boymomma473 :
My mother died of dementia/Alzheimers possibly. It is my greatest fear. I’ll be speaking to my doctor
2026-04-09 21:25:31
154
danigrlsdreams
danigrlsdreams :
Four months on zepbound, 16 years with systemic lupus. I havnt had a single day without pain. I have now had about 3 months with almost no pain. I went from walking maybe 3k steps a day, to now walking minimum 12k a day.
2026-04-10 04:27:39
37
katie_against_the_world
Katie :
I'm curious how it will work with fighting inflammation in autoimmune diseases.
2026-04-10 00:04:21
8
mnhockeygirl47
MNHOCkEYGIRL47🦋 :
You do what you have to do for your health. Good for you for being proactive
2026-04-09 17:05:58
73
beautyunseen
BeautyUnseen🎀🗝️ :
It’s reducing my inflammation
2026-04-28 23:01:08
5
apeymac68
ApeyMac68 :
I had a goiter for 30+ years which is now GONE after being on GLP1 for 2 years.
2026-05-07 21:00:50
5
jilly_bean630
Jillybean :
Both my parents have dementia. I will be on a GLP1 forever.
2026-04-09 18:38:00
49
gburkhart17
Beachlovegirl :
I had no idea that glp1s would help with Alzheimer’s. Good to know.
2026-04-09 20:33:33
128
conflenti
Conflenti :
I knew i opened this app for a reason today. Something to think about and investigate 🙏
2026-04-09 17:10:38
66
shaunajaynes
Shauna Mitchell 🆘🇺🇸 :
Taking it because of pre-diabetes but it took away my joint pain!
2026-04-10 01:50:58
19
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