@kikimusik1: DJ_TAKABEK_GADIH_RANTAU___DJ_MINANG_SLOW_FAUZANA_VIRAL_TIKTOK_TERBARU_2026

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Friday 10 April 2026 11:53:35 GMT
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If you have PMDD, you need to know about GABA 🧠 GABA is your brain's main calming neurotransmitter. It works to put the break on things, and keep mood stable. As progesterone rises and falls in your luteal phase, your GABA-A receptors should rearrange - like a puzzle piece shifting - to let more calming signal through and keep mood stable. In PMDD? Lower expression of the GABA receptor delta subunit is found in the luteal phase. This indicated that those receptors fail to rearrange properly in response to hormone shifts - and mood instability becomes a problem ❌ Scientists call this
If you have PMDD, you need to know about GABA 🧠 GABA is your brain's main calming neurotransmitter. It works to put the break on things, and keep mood stable. As progesterone rises and falls in your luteal phase, your GABA-A receptors should rearrange - like a puzzle piece shifting - to let more calming signal through and keep mood stable. In PMDD? Lower expression of the GABA receptor delta subunit is found in the luteal phase. This indicated that those receptors fail to rearrange properly in response to hormone shifts - and mood instability becomes a problem ❌ Scientists call this "GABA-A receptor plasticity failure" Your brain's brake pedal stops working exactly when you need it most. When GABA receptors can't properly regulate neuronal excitability, it also impacts the HPA axis - your body's stress response system - making everything feel even harder to manage. Stiernman L, Comasco E, Johansson M, Bixo M. Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder. Transl Psychiatry. 2025 Hantsoo & Epperson (2020) — Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids across the menstrual cycle. Neurobiol Stress Bixo et al. (2018) — Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder. J Neuroendocrinol #PMDD #pmddawareness #GABA #hormonehealth #lutealphase

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