@pathologicpathologic: From a healthy artery to a blocked vessel — this is how cardiovascular disease develops Endothelial dysfunction triggers reduced nitric oxide, inflammation, and oxidative stress, allowing LDL into the artery wall where it becomes oxidised. This activates immune cells, forming foam cells and plaque. Over time, the plaque narrows the artery until it ruptures, forming a clot that can cause heart attack, stroke, or limb ischemia. Full research sources: https://pubmed.ncbi.nlm.nih.gov/35722128/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12504828/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9199460/ https://pubmed.ncbi.nlm.nih.gov/31354915/ https://pubmed.ncbi.nlm.nih.gov/10608719/ #ScienceExplained #fyp #viral