@drjuhikmdphd: Replying to @ImYoo what labs do we check for lupus or SLE and why? Let’s talk about C3 and C4 the complement proteins that no one talks about enough. These proteins and their levels in your blood can be very helpful in diagnosing lupus or a lupus flare. Send along any questions you have! #lupus #lupuswarrior #autoimmunedisease #medicine

Dr. Juhi MD, PhD
Dr. Juhi MD, PhD
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Tuesday 21 April 2026 21:13:56 GMT
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drewz52736
KNoneYo :
I have Lupus and my C3 & C4 are always normal. No matter if Im flaring.
2026-05-10 01:14:40
21
marshmallowcat45
MarshmallowCat :
Positive Ana for lupus, but negative dsdna. What does that mean?
2026-04-22 16:48:15
6
ericarivera5317
Erica :
what about high c3 and c4 positive ANA with a speckled pattern. plus high sed and esr. mpv high, white blood cells high. every other test normal?
2026-04-22 04:40:17
0
felicia__felicia
felicia :
can ANA be negative if someone has lupus ??
2026-04-22 23:32:03
5
tidbit10
tidbit10 :
What about high? My total is high and c3 is high. CRP a smidge high.Ana high both homogenous and nucleolar. I can’t find ANY answers online. Seems to be a weird mix of results. No sub component tests for specific diseases are positive. I have hypermobility spectrum disorder too.
2026-05-07 19:15:39
7
aspiemama4
Kaylan Tucker :
I am 30 years old and just got a positive ANA with Chromatin. I have symptoms and off and on abnormal bloodwork/issues with kidneys. What is chromatin? I can’t find much on it
2026-05-12 22:25:00
5
harleydavis23
harley davis :
what's your take on c3@146, c4@24, positive ana, speckled and homogenous pattern, high ALT, low ACTH. I'm doing research on lupus and trying to become leveled in the office. all of my symptoms point to lupus but my doctor is hesitant. what's your quick take?
2026-04-22 03:37:34
5
sdpurkey75
sdpurkey75 :
My wife's C4a is 2850 and her ANA is 1:1280, speckled. Doctors say nothing to worry about, but it seems like it would be. Have you ever seen anything like this?
2026-04-22 20:13:55
6
health.journeys
Health Journeys :
Have you treated for Sjögrens? Wondering if Sjögrens can affect the vocal cords? I got laryngitis out of the blue with no infection(s). I am going on 60 days. I tested + for Sjögrens. But my Rheumatologist said he didn’t know if Sjögrens affects the vocal cords. Thoughts?
2026-04-21 21:38:04
6
lcherry18
Lauren :
what if only the c3 is low?
2026-04-21 21:25:07
6
crziebird
crziebird :
What about when C3 and D-Dimmer are high?
2026-05-07 15:11:53
5
rachelcutter1
Rach Cutt :
If c3 & c4 are low, but ANA and everything else on lupus panel is normal, what are some of the other differential diagnoses you consider?
2026-04-22 00:22:18
6
kelsmorgan4580
Kels Morgan :
One of the best explanations I've seen! Thank you 😊
2026-04-22 20:27:46
5
deanaely
D Marie :
My C3 is normal but my C4 is low…
2026-04-24 15:26:10
5
noguts_nostory
KarlaEliana :
What other labs do you check?
2026-05-19 12:01:51
5
user731245957851
JDD :
Mine were low and I was diagnosed with sjogrens.
2026-04-24 02:17:00
1
lillyacosta27
Lilly Acosta :
Can endometriosis cause these test o be slightly elevated ?
2026-04-23 19:08:39
5
danannmsn
danannmsn :
Thank you! So helpful as a primary care NP❤️
2026-04-23 23:01:49
5
meganwernert
Megan W :
Great way to break it down. Thank you for this! Easier for my brain to digest 😅
2026-04-21 21:18:32
8
lindsdb93
ℒ𝒾𝓃𝒹𝓈ℯ𝓎ℬ⚡️🥀📚 :
🥴 I am wondering if I have it.
2026-08-08 01:34:07
0
crystal_lynn80
crystal_lynn80 :
My C3: 233 (high), my C4: 45 (high) CRP is 24 and my Ana is positive Speckled 1:40 * Spindle apparatus 1:40 WHAT DOES THIS MEAN
2026-05-29 01:40:38
2
ceciliachavira608
ceciliachavira608 :
This was very helpful information. Thank you!
2026-05-09 00:09:49
4
stingerbish
StingerBish :
I’m waiting to see if I have seronegative lupus. All the labs are negative and WNL with the exception of C3 & C4 are both Low. I just want answers for how I’ve been feeling.
2026-06-17 01:50:22
3
desert_rain_worship
DesertRainWorship :
my dr will only check ANA. says if its negative no way I have any autoimmune including lupus.
2026-05-04 01:55:50
3
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