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![Ellen Pompeo, Patrick Dempsey, Sandra Oh, Justin Chambers, Katherine Heigl, T.R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington, and Kate Walsh headline the definitive 10-member ensemble retrospective for the monumental 2005 inaugural season of ABC's medical titan, Grey's Anatomy Season 1. Created by Shonda Rhimes, the 9-episode mid-season debut reshaped modern television, chronicling the intense world of Seattle Grace Hospital. The dual structure was led on the ground by the legendary surgical intern class known as MAGIC: 36-year-old Ellen Pompeo as Meredith Grey, 34-year-old Sandra Oh as Cristina Yang, 27-year-old Katherine Heigl as Izzie Stevens, 35-year-old Justin Chambers as Alex Karev, and 32-year-old T.R. Knight as George O'Malley. Overseeing their trials were the hospital's senior staff: 39-year-old Patrick Dempsey as attending neurosurgeon Derek Shepherd, 36-year-old Chandra Wilson as resident Miranda Bailey, 51-year-old James Pickens Jr. as Chief Richard Webber, 42-year-old Isaiah Washington as cardiothoracic head Preston Burke, and 38-year-old Kate Walsh, who delivered one of television's greatest season finale cliffhangers as Addison Montgomery. Exactly 21 years have passed since the doors of Seattle Grace first swung open. Witness the real, entirely unembellished facial journeys from their career-defining 2005 launch to their status in 2026, captured cleanly in a single comparative image. 📸 🎬 Grey's Anatomy Season 1 Full 10 Cast Timeline Summary (2005 Premiere vs 2026 Status) [MAGIC Interns] • Justin Chambers [Alex Karev] (Born 1970-07-11) : Age 35 in 2005 ➔ Age 56 in 2026 • Sandra Oh [Cristina Yang] (Born 1971-07-20) : Age 34 in 2005 ➔ Age 55 in 2026 • Ellen Pompeo [Meredith Grey] (Born 1969-11-10) : Age 36 in 2005 ➔ Age 56 in 2026 • Katherine Heigl [Izzie Stevens] (Born 1978-11-24) : Age 27 in 2005 ➔ Age 47 in 2026 • T.R. Knight [George O'Malley] (Born 1973-03-26) : Age 32 in 2005 ➔ Age 53 in 2026 [Attending Physicians & Residents] • Isaiah Washington [Preston Burke] (Born 1963-08-03) : Age 42 in 2005 ➔ Age 63 in 2026 • Chandra Wilson [Miranda Bailey] (Born 1969-08-27) : Age 36 in 2005 ➔ Age 57 in 2026 • Patrick Dempsey [Derek Shepherd] (Born 1966-01-13) : Age 39 in 2005 ➔ Age 60 in 2026 • James Pickens Jr. [Richard Webber] (Born 1954-10-26) : Age 51 in 2005 ➔ Age 72 in 2026 • Kate Walsh [Addison Montgomery] (Born 1967-10-13) : Age 38 in 2005 ➔ Age 59 in 2026](/video/cover/7702070872558947605.webp)
