@dr.zac.spiritos: Mast cell activation syndrome is rarely a “random” problem—more often, mast cells are reacting to something upstream. One pattern I see frequently in clinic is a history of chronic infections, sometimes pointing toward an underlying immune vulnerability. Conditions like Specific Antibody Deficiency or Common Variable Immunodeficiency can make it harder for the body to effectively clear infections, leading to repeated immune activation. When that happens, mast cells stay on high alert, doing exactly what they’re designed to do, but in the process, they can drive a wide range of symptoms. What’s interesting is that when we identify and treat these underlying issues, whether that’s improving immune function or reducing infection burden, patients often feel significantly better. Not just because they’re getting sick less, but because the constant trigger keeping their mast cells activated is finally addressed. It’s a good reminder that mast cells aren’t the problem, they’re the responders. If they seem “overactive,” it’s worth stepping back and asking what’s keeping them activated in the first place. #mcas #heds #ehlersdanlossyndrome #hypermobility #dysautonomia

Dr. Zac Spiritos

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Wednesday 22 April 2026 21:31:00 GMT