@drtimmercer: Replying to @missheaddesk Treatment resistant depression is not always as it seems, often there’s something else in the background, which is probably the same for treatment resistant anything but for depression we get to see it frequently. I am “just a GP” so I would defer to a psychiatrist for more, as they see the tougher stuff and do these extra treatments for people (if they still exist in your area) Things to consider in treatment resistant depression: OCD, EUPD/BPD, Bipolar type II disorder, ADHD, Autism, etOH/drugs/gambling addiction, Domestic abuse scenarios, and all other things Shout out to the social prescribers who are sorting most of these things nowadays #depression #MentalHealth #adhd #ocd #gp
Dr Tim Mercer
Region: GB
Thursday 30 April 2026 05:28:33 GMT
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A-D 🐼 :
I was diagnosed with treatment resistant depression after a good 20 or so years of things not improving. January was diagnosed with adhd after a referral from a new gp looked at me with a fresh pair of eyes and noticed that it was actually my feelings of failing to be a functional human that made me feel depressed rather than depression making me struggle to function. (Honestly I’m a pretty experienced therapist and totally failed to connect those dots myself haha!) I started methylphenidate, functioning improved and like magic I now really love life and my mood has never been better. (Even after pretty horrid bereavement and catalogue of awful events my mood has stayed stable (aside from normal griefy feelings). (Not saying that it’s a magic cure for everyone by any means, but definitely shows how important the right diagnosis is, and also what a huge difference a curious gp can make to someone’s life!)
2026-04-30 13:02:28
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Ruth Fox :
As someone with EUPD, I hate the diagnosis name. Wish someone had named it something else 🥲❤️. What do you mean my personality is disordered along with my mood, my relationships, my stability, my safety, my job, my hobbies etc.
p.s thank you for your videos and normalising these conversations x
2026-04-30 16:59:22
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🖤 :
thank you for your kind words about how upsetting it feels to be diagnosed with a personality disorder. i know it was in passing, but i appreciate when dr’s can acknowledge the stigma we put onto PD patients. i was 18 when i was diagnosed and it was something that made me feel so abnormal and broken
2026-04-30 12:44:40
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Chemfinn :
I guess i have TRD going by the definition but i don't think any of my doctors ever used the term, but i tried 4 different antidepressants (SSRIs and a NDRI) and tDCS over the course of like 10yrs before getting put on 15 mg vortioxetine, it definetely has been the most effective one for me but it is a bit of a balancing act with the nausea 😅
2026-04-30 16:28:51
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RJ💜🌟 :
I was told I had treatment resistant depression and put on mirtazapine, venlaflaxine and Quetiapine at the same time. But they hadn’t tried psychotherapy and when I finally got to try the right type of therapy, it helped! I feel like therapy gets forgotten when it’s an important part of treatment for depression
2026-04-30 16:09:13
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Louisa T :
I've been on California Rocket Fuel for nearly a year and I won't lie, the main upside for me has been getting to the say the name a lot. I can't say I've noticed much difference other than stronger side effects from both meds. Hoping ECT or even medical (es)ketamine might be more helpful, if it comes to that
2026-04-30 22:41:07
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Ffionforthewyn :
I was on a medical trial with pramipexole (the Pax-D trial) to treat treatment resistant depression. it worked really well
2026-04-30 19:03:25
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Elisha Killeen :
I have eupd anxiety depression and ptsd I was taking the rocket fuel but this made me feel like i was drunk the next morning but I drive as a district nurse so had change meds x
2026-04-30 14:26:24
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Paraeducator Sarah :
I love it how your newborn is learning along with us. 😁
2026-04-30 06:27:44
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Zoë 🌸 :
The psych I work with taught me about treatment resistant depression and California rocket fuel! 🚀
2026-04-30 17:31:31
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Alex :
is it worth going down the ADHD diagnosis route? I feel thats what my 'depression' is. Seems a hassle tho
2026-04-30 19:54:12
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🏳️🌈🏳️⚧️🤟Ali Als 🐈⬛🐈🧶 :
I have heard of it. I tried Venlafaxine. it made my mind feel much better, but the side effects were awful for me.
2026-04-30 14:48:24
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happyhippy71 :
I experienced trd in my last bipolar episode and I’m not in a hurry to go
2026-05-01 17:36:06
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Lucy Mac :
did you hear about the sertraline recall? would love to hear your views on it
2026-04-30 18:58:30
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Kaz Brearley :
Your newborn is so cute. 😍
2026-04-30 07:44:51
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Georgia-Leah Simpson :
I even tired that 😭😭😭 venlafaxine and mirtazapine didn’t do it for me!
2026-04-30 05:36:09
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Johnathan :
Wait why did I think you had a towel over your shoulder 😭 then to realise it’s your newborn
2026-04-30 07:00:30
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Georgia-Leah Simpson :
Dunno why I’m telling u my life story
2026-04-30 05:37:36
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Kaz Brearley :
Thank you for the video on this subject. Hadn’t heard of California Rocket Fuel before.
2026-04-30 07:44:26
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JessiD :
Currently on cali rocket fuel I feel like my brain is just going way too fast and I’m bouncing around like a child then I crash back in to depressive episode 🙃🙃
2026-05-01 19:29:15
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Paul :
I'm diagnosed EUPD and GAD with depression that's never been helped by medicine that I've had offered. I think the dx is only partly correct - I'm now fairly sure that I'm living also with some neuro diversity (potentially). I've had serious mh issues for 40 years. In my area they have closed the waiting list (due to demand). I'll try anything now. Anything... ...
2026-04-30 11:23:58
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Hannah88🐈⬛ :
aww little Baba is learning too 💞
2026-04-30 08:15:51
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Johnathan :
I had this with two antidepressants but then the next worked 😁 maybe I’m the odd one out lol
2026-04-30 06:59:50
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Cambayog :
i was “mistakenly” diagnosed with depression but it turned out to be OCD. However, the prescribed treatments, antidepressants and CBT, are also the treatment for OCD, so they worked fantastically! I ❤️Sertraline (except that it made me fat)
2026-06-10 02:27:49
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highlightshadow 🇬🇧 :
I haven't responded to 18!!!! medications. 11 in the past 12 months. I'm done with it. I need help but help is impossible
2026-05-12 15:25:28
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