@ladyspinedoc: For over 60 years, we thought metformin worked mainly through the liver and gut. But new research suggests the brain may play a major role too. This study identified a specific brain pathway (Rap1 in the hypothalamus) that appears critical to metformin’s glucose-lowering effects, potentially reshaping how we understand one of the world’s most prescribed diabetes medications.   Source: Sci. Adv. 2025;11:eadu3700

Nurse Cole • LPN 🩺 💜 :

I just found out Metformin is linked to being on dialysis with long term use. I immediately stopped taking it when my endo confirmed it.

Kelsea :

Is it common to feel depressed when taking metformin?

Dagan🧕🌹🌼 :

Is metformin also taken for PCOS

Audrey Lambert :

Just started took my first dose this evening, for pcos and pre diabetic, very nervous.

AV Sourdough :

it gave me short term memory loss

OmgRonnie!🎶🍿 :

That’s so beautiful. I swear, one good thing always leads to another.

Swimmer97 :

Insulin also acts on the hypothalamus

deedrown :

i take it for pcos

s c a r l e t 🧿 :

Metformin helped me sooo much with my pcos

Holly :

Can you have had a mini stroke without it showing up on a CT or MRI scan? Thank you.

Her Ladyshqip :

Is creatine good or bad for brain?

Sash Finds :

I wish I could take metformin to enhance my gl🫛 1 effects but it makes me soooo sleepy that I can’t even function.

Rida Zeineddine :

It’s very good for brain fog

Papa Doc 👨🏽‍⚕️ :

Can we have a link for the study pls?

Skygazer111 :

if someone has ckd and diabetes how safe is metformin for them?

This some shit :

I have a spinal cord injury and my blood sugar spikes and drops . Makes sense to me! lol

Rebeca :

I was told Metaformin has memory loss side effect. I’m not 40 yet can’t remember anything

Mel-a-Don :

It make me so sick

Fidhaaaa :

What about the side effects to the kidneys?

🐈‍⬛ :

What do you think about berberine? They say it acts similar to this

passivesigh :

Tricia_cottoncandy_lette🖤 :

Metformin was gave to me for my type 2 diabetes and it gave me the crap

Hannah | Dumpster Diver 🦝 :

I'm not a scientist but I do feel like this should've been common sense. The brain gut connection?

Andym1722 :

Thank you again for a very interesting and informative video. ❤️