@todayshow: GLP-1s like Wegovy and Zepbound are transforming the weight loss landscape but along with physical changes, a number of patients are reporting a loss in joy or pleasure. The reports of the unexpected side effect, which some dub “Ozempic personality,” are all anecdotal, but weight loss drug patients across social media are opening up in growing numbers. NBC’s Anne Thompson spoke with Dr. Christopher McGowan about anhedonia, the loss of interest or joy, and its potential ties to GLP-1s, for TODAY.

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Tuesday 19 May 2026 17:00:08 GMT
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unbothered4271
Unbothered :
No way, I’ve never been happier
2026-05-19 19:55:50
680
carinaeberle
carina :
This 10000% happened to me! I had to stop the glp 1. I could go to Disneyland and not feel and ounce of joy.
2026-05-21 23:10:06
11
lyssbees
Catgirl711 :
Actually, my depression and anxiety improved.
2026-05-20 04:13:35
337
heidithejoy
Heidi Helstad :
This is ridiculous. I’ve been on ZB for a year and a half now and feel joy every day and haven’t been happier and food tastes as good as it always has. 🤷🏻‍♀️I’d probably be even more happier if I didn’t have to pay over $400 a month for it.
2026-05-20 13:10:26
74
higigicamp
GigiCamp :
I have noticed this - it’s made me a hermit
2026-05-20 01:33:28
108
fuckthehighroad
Fuck-the-high-road 🩵🌊 :
Because my only joy was food 😏
2026-05-20 00:27:57
121
michelle.california
michelle.california :
I’m OK with that. I’m finally skinny.
2026-05-19 19:54:22
108
mistymuller
Misty :
Gave me the worst anxiety.
2026-05-20 18:54:48
5
nicolegagne40
nicolegagne40 :
It's true.I had to stop after two months because there was just this nothing
2026-05-20 13:16:11
7
crisy_ss
Crisy S. :
I definitely struggled with feeling this way - had no idea it was my glp1. Once I lowered my dose because I didn’t want to lose more weight, I instantly felt like myself again. I’m glad there’s reporting on this. I wish I had known sooner. Very hard season for me.
2026-05-20 01:47:19
14
lisacampbell4521
Lisa 💙 :
It’s the opposite for me. Doing wonders.
2026-05-20 20:25:45
68
julie_pom_diamondpaints
Julie Pom Diamond Painting :
I have this but it’s just from watching the news.
2026-05-20 09:46:16
15
sunny_in_socal
SunnyInSoCal :
Disagree! Never been happier.
2026-05-20 01:53:30
59
thegrapeape78
thegrapeape78 :
I am more relaxed and happier! Kinda crazy how my anxiety is so much better
2026-05-19 22:29:19
32
sweetener232
sweetener232 :
This is the happiest I’ve ever been
2026-05-21 17:27:28
13
yuri22552
Yuricowz :
I have this, it's not 100% but it's about 50%. Really sucks.
2026-05-20 10:49:19
5
positivelytracey
PositivelyTracey :
My Mounjaro definitely makes me feel like my personality is flat. It’s gotten slightly better and er the tears but it’s definitely a thing.
2026-05-19 22:32:55
17
nvco303
NV :
lol not true … whattttttt
2026-05-20 12:17:43
6
iamkingfluffy
Tony :
Or it's just the past 10 years of life.
2026-05-20 14:26:54
11
erinelaine86
Erin :
I feel the opposite. The food noise being gone gives my brain so much more clarity, and I find it easier to focus on the things I enjoy.
2026-05-20 09:50:26
15
michellebaugh445
Michelle Baugh :
I was on Wegovey and Zepbound & my depression got so bad it scared me
2026-05-20 11:16:35
6
larkiejets
Lauren :
It’s very real and so awful. Never again.
2026-05-20 12:33:59
7
maggietipping
Maggie :
Opposite for me. I’ve been able to cut back on anti depressants
2026-05-21 02:08:03
5
maryjo_la
Mary Jo :
Hard disagree. HARD.
2026-05-20 17:47:42
9
tiffanyrangino
Tiffany R❌ :
I can’t stop shopping. That’s my pleasure
2026-05-20 03:13:07
17
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