@thepowerdoctor: LH and FSH act on the leydig cells and sertoli cells in the testes. This leads to testosterone production and spermatogenesis. When LH and FSH are high = primary hypogonadism if testosterone is low. When they're low, it is secondary hypogonadism. There is nuance to having inappropriately normal gonadotropin levels as well. #lowtestosterone #hypogonadism #hormones #trt #Medicine (disclaimer: not medical advice)