@instituteofhumananatomy: 🧠 Your brain has a built-in pain control system — and it works a lot like opioid drugs. Here's how: After pain signals reach the brain, the brain fires signals back down the spinal cord to dial the pain down. This is called the descending pain pathway. A region in the brain stem called the periaqueductal gray triggers the release of endogenous opioids — your body's own natural painkillers — that reduce how strongly pain signals travel back up to the brain. Think of it like a volume knob. Your body doesn't eliminate the pain entirely — it turns it down to a manageable level. And that's actually a survival advantage, so pain doesn't become completely overwhelming. 🎚️ Here's where it gets serious: drugs like fentanyl hijack this exact system and amplify it to an extreme degree — far beyond what the body was ever designed to handle. ⚠️ Follow for more anatomical awesomeness! #tiktoklearningcampaign #anatomy #humananatomy #pain #nervoussystem #painmanagement #opioids #fentanyl #endorphins #neuroscience #brainfacts #spinalcord #physiology #anatomyandphysiology #medschool #premed #learnontiktok
Technically the brain doesn’t directly modulate the pain sensation. Only the spinothalamic tract reaches the thalamus and then the cortex. The true modulator is a closed circuit that begins with the pain sensation with a Aδ/C that activates a WDRN. The WDRN activates the PAG where the oppioid-ergic interneuron inhibits (thanks to μR, κR and δR) the projection neuron (GABA-ergic) activating the Nucleus of the Raphe Magnus (Serotonin-ergic) and the Locus Coeruleus (NORA). These two pathways inhibit/regulate the WDRN in a direct way (Noradrenergic - Raphespinal tract) or through an oppioid-ergic interneuron (Serotoninergic - Coeruleospinal Tract)
2026-06-09 18:45:25
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First this is very interesting
2026-06-09 15:03:19
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2026-06-09 15:04:27
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Ada. :
😌😌😌
2026-06-10 17:54:21
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