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@ohh_luce: Winter in Queensland? We don’t know her 💅 #winter #australia #winterfit #OOTD #visa

ohh_luce
ohh_luce
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Region: AU
Wednesday 01 July 2026 03:49:19 GMT
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Hereditary alpha tryptasemia (HαT) is a genetic condition where people carry extra copies of the TPSAB1 gene. It’s found in roughly 5 to 7% of the general population, making it relatively common. A 2024 paper by Wagner et al. and a 2024 paper by Polivka et al. in the Journal of Allergy and Clinical Immunology synthesized evidence that HαT is significantly over-represented in patients with mastocytosis (12-20%), idiopathic anaphylaxis (around 17%), and chronic mast cell symptoms. HαT is associated with elevated baseline tryptase, female sex, thyroid disorders, GI symptoms, and severe allergic reactions. The diagnostic test is TPSAB1 droplet digital PCR (ddPCR), which counts gene copies. It costs roughly $200 to $300 in the US. HαT is a genetic modifier, not a disease on its own. Many carriers are asymptomatic. The test doesn’t diagnose MCAS, and not everyone with mast cell symptoms has HαT. Diagnosis of mast cell disorders should be done by a specialist. I’m not a doctor, just sharing research I find interesting. Sources: Wagner et al. (2024). PMC11588693 Polivka et al. (2024). Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2023.08.015 2025 Greek case series. Journal of Personalized Medicine. DOI: 10.3390/jpm15040196 #mastcellactivationsyndrome #mcas #allergies #research
Hereditary alpha tryptasemia (HαT) is a genetic condition where people carry extra copies of the TPSAB1 gene. It’s found in roughly 5 to 7% of the general population, making it relatively common. A 2024 paper by Wagner et al. and a 2024 paper by Polivka et al. in the Journal of Allergy and Clinical Immunology synthesized evidence that HαT is significantly over-represented in patients with mastocytosis (12-20%), idiopathic anaphylaxis (around 17%), and chronic mast cell symptoms. HαT is associated with elevated baseline tryptase, female sex, thyroid disorders, GI symptoms, and severe allergic reactions. The diagnostic test is TPSAB1 droplet digital PCR (ddPCR), which counts gene copies. It costs roughly $200 to $300 in the US. HαT is a genetic modifier, not a disease on its own. Many carriers are asymptomatic. The test doesn’t diagnose MCAS, and not everyone with mast cell symptoms has HαT. Diagnosis of mast cell disorders should be done by a specialist. I’m not a doctor, just sharing research I find interesting. Sources: Wagner et al. (2024). PMC11588693 Polivka et al. (2024). Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2023.08.015 2025 Greek case series. Journal of Personalized Medicine. DOI: 10.3390/jpm15040196 #mastcellactivationsyndrome #mcas #allergies #research

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