@erinrackham: Week 1–Guanfacine for hyperadrenergic POTS (.25 mg IR). I still feel more sedated than normal (napping every day right now), but I’m also staying out of fight/flight, which feels great. My executive functioning is improved, heart rate is more stable & lower, and cold intolerance is still better. It feels like Guanfacine is “good, not great”, so far, but I want to give my body time to adjust and see how I feel in a few weeks! #Guanfacine #HyperadrenergicPOTS #HyperPOTS #longCOVID

Erin Rackham, PhD
Erin Rackham, PhD
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Thursday 09 July 2026 15:13:13 GMT
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lindseyasbery
Lindsey Asbery :
Day 3 of 1mg ER guanfacine gave me terribly low blood pressure and low sleeping heart rate, had to stop.
2026-07-09 17:18:22
2
futrzak13
Monika :
I reacted bad to guanfacine, I like clonidine much more.
2026-07-10 04:37:24
2
saisx1
saisx1 :
I’m on half dose of clonidine and it’s better
2026-07-12 08:37:37
1
lexih0404
Lexi • Building For Papa :
Can you take this with propranalol?
2026-07-09 22:36:56
0
sandiegointeriordesigner
Savvy Interiors | San Diego CA :
I’ve read that it takes a few weeks to regulate, I’m 4 days behind you on 1/2 a tab at night. So far so good
2026-07-09 21:07:04
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jvayn
Jody Vaynshtok :
Same observations for me. The sedation was too much and although all those pros the sedation made me stop after trialing for three weeks.
2026-07-09 15:21:48
2
lifeherway_
lifeherway_ :
Are you only taking Guanfacine or do you pair it with something else
2026-07-12 05:44:07
1
raenez716
Rae 🌸 :
What are your symptoms associated with hyperandregeneric pots and how were you diagnosed?
2026-07-10 16:15:04
0
iamcorinne.d
Corinne :
I don’t understand how .25 would sedate you. My 5 year old was taking 1-2mg to help her sleep and she was wide awake 😭
2026-07-15 03:02:56
0
dara2233633
Dara :
Try the long acting
2026-07-11 03:48:46
0
living.autonomic
Bill RT(R) | Living Autonomic :
What is your cerebral blood flow looking like during all of this? I can’t speak to your case specifically but for me I have pretty severe cerebral hypoperfusion that is driving the dysautonomia symptoms hr and bp.
2026-07-11 18:03:00
1
lisasfullcircle
FullCircle💫Design :
I’m only taking it at bed time. I’m a little sleepy for awhile in the morning but my brain fog has noticeably decreased. Executive function has also improved. Someone said they take it at like 7pm so they aren’t so tired in the morning.
2026-07-10 01:13:21
1
diegbl
Diegbl :
I have some excessive sweating as a side effect 😭 do you feel it could help with that bc of the sympathetic effect? Beta blockers helped a little for me
2026-07-10 16:42:18
0
punklivez
Raising River :
Would you mind doing a video recapping everything you are on/doing?
2026-07-09 18:41:56
0
centralperk1252
Centralperk :
How has it affected your blood pressure? Mine is low so I haven’t tried it yet
2026-07-11 14:02:19
0
strawbunni.nails
StrawBunni.Nails :
Can I ask what your blood pressure looks like and if it was affected? My blood pressure sits on the lower to mid side but my pots symtoms a sympathetic so I’m scared to try
2026-07-09 20:15:19
0
brittnyrae
Brittny :
My daughter has been on Guanfacine for 5 years and the extended release did not work for her, like she never even took it
2026-07-11 07:32:44
0
erica.mcclellan
Erica McClellan :
Guanfacine made me sooooo irritable!
2026-07-09 15:30:49
0
nuckyduck
Nuckyduck :
I have a tilt test in October. Not looking forward to it.
2026-07-09 19:10:43
1
riganwuzhere
Rigan :
Thank you for posting about this experience. I've just been diagnosed with hPOTS.
2026-07-09 18:06:27
0
pureleaficetea
bob :
when i was on ER guanfacine for adhd i was super tired for the first couple weeks but it did kinda go away as time went on
2026-07-12 03:31:32
0
lisasfullcircle
FullCircle💫Design :
Also my doc said give it a month before deciding the side effects aren’t worth the benefits.
2026-07-10 01:14:17
0
riotgirlonfire
riotgirlonfire :
Guanfacine leveled out for me! Also I found 1mg extended release has a much smoother effect for me. You can’t split the pills but I found 1mg ER at night helped w insomnia and carried over into the AM well.
2026-07-09 16:17:18
3
siranaiy0
🫶🥺 :
when I started propranolol I was exhausted for weeks, but I think it was my body adjusting from being in fight-or-flight for soooo long. maybe this is what’s happening to you too? i’ve been on a low dose of ER Guanfacine now for over a year now and it has helped my nervous system so much 🥰
2026-07-09 18:16:17
0
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