nickbischoff.np
Region: US
Thursday 09 July 2026 16:11:06 GMT
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flit_fox :
I had a poor reaction to a traumatic event in my life and they tried to immediately put me on antidepressants. Before that or since healing I have never been depressed, it’s normal to react to things that happen.
2026-07-10 02:48:02
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100000000me :
So what exactly HAS been wrong with me since the age of 5? And why am I functional on 2 meds? I’ve done therapy and made a good life for myself. I just happen to have something wrong with my brain
2026-07-09 22:09:43
231
Temilola Aye :
Ok then what’s your answer for treating depression
2026-07-09 21:06:38
147
OnlyPatricians :
The chemical imbalance theory was not being taught anymore at least in 2017-2018 ish when I did my psych degree.
2026-07-10 02:47:02
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Carrinabeth :
as a psychology major, what are you talking about
2026-07-10 22:32:31
1
Paxcordis :
First I’m hearing about this
2026-07-09 20:46:13
140
Katie Van Brunt :
Girl, my CYMBALTA keeps me going (FWIW I’ve been working with treatment résistant depression for 20+ years)💅
2026-07-09 23:01:39
73
Sarah Marie8191 :
Effexor was a life savor for me. I finally wanted to get out of bed, I finally was getting to work on time. Life is great
2026-07-10 16:14:30
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josh :
I don't understand. you're saying serotonin deficiency doesn't cause depressed mood? I know we don't exactly know what serotonin does, but I feel like SSRI's work way too well for serotonin to not be a fundamental factor of depression
2026-07-10 00:26:34
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borgo420 :
Zoloft was very helpful when I needed it. The side effects however were almost as damaging as the depression it was treating and getting off it SUCKED
2026-07-09 23:32:57
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Blue Marigold :
Lexapro saved my life. So.
2026-07-10 17:18:42
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Wyo-Dad :
MS in counseling. I was taught that it only does about 5 percent better than a placebo.
2026-07-09 20:40:12
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Cassandra Z :
huh? I don't understand what dude is talking about. can someone explain?
2026-07-10 00:42:05
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Oct :
1950s–1960s: Researchers observed that drugs affecting serotonin, norepinephrine, and dopamine could improve symptoms in some patients. This led to the monoamine hypothesis, proposing that deficiencies in these neurotransmitters might cause depression. 1970s–1990s: Despite growing public messaging that depression was due to a “chemical imbalance,” researchers increasingly acknowledged that direct evidence for this explanation was weak. Textbooks and scientific reviews described it as a hypothesis rather than a proven mechanism. 2000s: Advances in brain imaging, genetics, and neurobiology showed depression is far more complex. Studies failed to consistently find lower serotonin levels, fewer serotonin receptors, or other simple biochemical deficiencies in people with depression. 2010s: Many leading psychiatrists and neuroscientists publicly stated that the chemical imbalance explanation was an oversimplification. The field shifted toward models involving genetics, stress, neuroplasticity, inflammation, endocrine function, neural circuitry, and environmental factors. 2022: A major umbrella review led by Joanna Moncrieff, published in Molecular Psychiatry, concluded there was no convincing evidence that depression is caused by low serotonin or a serotonin deficiency. While the review was widely discussed, many experts noted that this reflected what much of the scientific community had already believed for years rather than overturning established science.
2026-07-10 13:04:22
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None :
I took college psych in 2011, it was in the textbook 😳
2026-07-10 18:03:58
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Vel169 :
My profession,(school psychologist at Title 1 high schools), works in coordination with psychiatrists that provide on-site services). And every one of them is in agreement with you about anti-depressants. Their expectation for them to treat depression is low. The nuero-chemical reasoning for their conclusion was explained to me but I found it complex
2026-07-10 00:11:20
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Cassie Lee's Bookshop :
I’m honestly confused. What are they saying causes it now?
2026-07-10 15:37:19
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Ellie :
I specifically remember getting a pamphlet on depression and meds from my doctor that spelled it out.
2026-07-10 02:26:18
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Emily Deeeeeeee :
Tell us more about
2026-07-09 21:48:15
8
DrillersLady :
It *was* taught sort of, a psychiatrist and pharmacist came to one of my nursing classes in 1992, a bridge program LPN to BSN and held a 4 hour class on this very thing.
2026-07-09 20:41:00
5
Lindsay Walker613 :
So what is the cause? Do we know that yet?
2026-07-10 02:59:43
1
The Dog Lady :
Elite ball knowledge.
2026-07-10 13:02:01
3
CMC :
Wait what?
2026-07-09 23:24:52
0
Baddieideabear :
So then what is going on because I know my Concerta works
2026-07-10 01:18:43
2
nodietcokes :
What does new info say about mood stabilizers like Lamictal? Have we misunderstood their efficacy the same way as antidepressants?
2026-07-09 23:21:57
4
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