@drsermedmezher: Bone Marrow Transplant Before Pregnancy? #explain. Sources- PMID 9263673 junkmotherjess on TT When a patient receives an allogeneic bone marrow transplant, they technically become a genetic chimera because their body now harbors two distinct sets of DNA. The transplanted hematopoietic stem cells take up residence in the recipient's bones and begin churning out blood and immune cells that carry the donor’s genetic profile, while the rest of the patient’s organs and tissues retain their original birth DNA. This hematopoietic chimerism can be transient or permanent for the blood system, but it remains strictly compartmentalized within the circulatory and immune networks. This cellular fusion completely bypasses the recipient’s reproductive system, meaning the genetic makeup of their eggs is entirely unaffected. Eggs are formed during fetal development long before a transplant occurs, and they reside safely within the ovaries, completely isolated from the circulating blood stem cells. Because the transplanted donor cells only generate blood and immune lineages, they cannot infiltrate the germline, ensuring that any biological children a patient has after the procedure will inherit their original maternal DNA rather than the donor’s. #transplant #pregnancy #women

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2026-07-20 20:33:58

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