@dliftstok: Why cycling isn't always about receptor desensitization.Most of the cycling discussion in this space centers on receptor desensitization. Clinical literature complicates that framing. Tesa specifically runs in trials from 26 to 52 weeks, continuously with sustained IGF-1 response and no observed tachyphylaxis. If the compound with the strongest theoretical case for down-regulation doesn't show it, the receptor argument needs re-examining. The most defensible concern is cumulative exposure, aka compensatory adaptations, altered signaling environments, and long-term endpoints that have never been studied. Research use only, not for human consumption #PeptideScience #ReceptorDesensitization #Washout

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Wednesday 22 July 2026 17:37:27 GMT