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Friday 31 July 2026 23:25:16 GMT
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David Friedberg on Modern Wisdom with Chris Williamson
David Friedberg on Modern Wisdom with Chris Williamson "How far off are we from age reversal? One decade, five decades? "Way less than that. Way less than that. We are in clinical trials now on several of these cocktails." "Every cell in our body has the same DNA. But what makes my eye look and act differently than my skin? Those cells are different because the genes in the DNA are on or off." "As we get older, it looks like what happens is we have DNA breaks. DNA gets damaged from radiation and sunlight and bad eating and alcohol and all the other shit. As those DNA breaks happen, your cell actually fixes the DNA. It's very good at fixing it. Every time the DNA gets fixed, there's a chance that those ones and zeros, those ons and offs get moved around a little bit. And as they get moved around over time, they get moved to the wrong place. And then that cell stops working right. The eye cell stops doing what it's supposed to be doing. And eventually, if enough of those cells have those epigenetic, is what it's called, epigenetic errors, you start getting wrinkles, your heart stops beating as well, you go blind, all these sorts of things happen with aging. It looks like the root of all disease may be aging." "In 2006, a guy named Shinya Yamanaka found that he could take four proteins and put them on a cell, and they would move all of those epigenetic markers, those ones and zeros, to make that cell into a stem cell, which can then be turned into any other cell in the body. So that was the magic thing he won the Nobel Prize for." "In 2016, another scientist published a series of papers showing that instead of putting a lot of those four proteins on the cell, you could put a small amount. Instead of resetting all those molecular markers and making that cell back into a stem cell, what it actually does, it just moves those markers back to where they're supposed to be, to make it a young cell. And suddenly that retinal cell becomes like a young retinal cell. All of these cells get reset. And they did this in mice and they made the mice age to like 250 plus years old. They put it in monkeys, the wrinkles went away." "But basically what this means is we are now discovering not just the four proteins, but a whole bunch of other little molecules that we can put into a cocktail. Either we're going to drink it, take it as a shot or take it as a pill. It will get into our cells and it will reset the epigenetic of that cell to make it young again. These proteins can be continuously made and released inside our body as they're needed. So we maintain our youth and we will live theoretically for as long as we want. That's where this is headed." — David Friedberg on Modern Wisdom with @Chris Williamson #davidfriedberg #chriswilliamson #modernwisdom #agereversal #artificialintelligence

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