Dr. Michele Oller, PharmD
Region: US
Tuesday 28 July 2026 17:30:27 GMT
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leopardeverything18 :
I tried the patch and gel estrodial over a few years to give them a good shot but my levels would never go up. Dr said bad absorber. Now on oral and levels are up to 45 but now my testosterone went from 57 to 19. Is there any way to increase my testosterone? Now that it’s low my joints hurt and I’m tired all the time and my confidence tanked.
2026-07-29 02:05:41
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JanetJamerson :
What about compounded torques? Thoughts?
2026-07-28 21:37:29
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Veronica :
This patch shortage is making reach out to my doctor to start the pill version.
2026-09-04 03:54:21
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Lisa :
The patch hasn’t been available in my area after 2 weeks off I got extremely sick again so now I’m on the pill only been on it a week so not feeling full effect yet
2026-07-29 16:36:32
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Tina B :
Are you more prone to migraines with oral estrogen? I hard a hard time with the patch bc it gave me too many ups and downs based on which day of applying it which gave me more headaches bc of the fluctuation.
2026-07-28 21:54:50
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Going my own way :
Oral E caused my BP to skyrocket from 125 to 160
2026-07-29 03:41:23
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BetterOffAutistic :
Doesn't high SBG also bind estrogen?
2026-08-01 16:04:31
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kmuse08 :
… what if I have all of those those risk factors‽? Patch 4ever. Got it 😂
2026-07-28 22:28:16
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FarmerFred :
most of the doctors I know use oral estradiol over transdermal estradiol. they use it specifically because it doesn't actually increase clot risk in any RCTs. Transdermal estradiol is more protective than oral estradiol for clots, but no single RCT shows that oral estradiol causes clots. In fact, studies show oral is protective against clots, just notnas protective as transdermal estradiol. Most people, physicians, specialists, erroneously extrapolate data from the WHI and other studies which used CEE (Premarin). Oral Estradiol and premarin are not identical, they do not affect the body the same and the body doesn't affect them the same. Oral estradiol prevents cardiovascular disease better than TD Estradiol, it lowers LP(a), ApoB, raises HDL, lowers A1c, and at low dose it slows progression of arterial plaques and at optimal levels actually reverses arterial plaques. Transdemal estradiol doesnt do this. Oral estradiol lowers visceral fat better than TD Estradiol. It raises triglyerciedes in some women early in the treatment, but when you lose visceral fat, it lowers triglycerides. By lowering visceral fat your lipids improve significantly, A1c even gets better. Insulin sensitivity improves. We don't see this with transdermal estradiol. Also, oral estradiol can get higher levels than transdermal estradiol, and it is able to regrow bone in patients with severe osteoporosis.
2026-07-29 04:51:25
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FarmerFred :
I think you are understating the evidence. Their are RCTs showing plaque reversal when used in menopause. There are RCTs showing slowing of plaque at low dose oral estradiol, because the authors were still afraid of using oral estradiol. There is still no single RCT showing the using oral estradiol causes clots. There are observational studies but not a RCT. There is reason why between 55 million and 350 million women have died due to the flawed and deadly WHI study scaring doctors from prescribing hormones to women in menopause. Most people don't actually know how to understand research. Dr. Csaszar @pamenshealthcare says it best. Don't compare the risks of a Ferrari, an analogous for CEE with a 1900 Ford, an analogy for estradiol. The risks associated with going 226mph in a Ferarri are not the same as going 10mph in the Ford. Yet, most doctors apply the risks of oral estradiol. This is wrong and should not happen. I could create an observational study showing that turning on a light switch is associated with women getting blood clots, heart attacks, and stokes, but no RCT would ever show causality. We would all say someone is nuts if they changed their practice and told others light switches should not be used because of an observational study. Yes, TD is more protective of clots, but oral is also protective against clots, too. It is not as protective as transdermal. Many doctors still use oral estradiol in women who are obese with CVD because the benefits outweigh the risks. I have yet to read a RCT showing transdermal estradiol is better at decreasing visceral fat compared to oral. I don't place a lot of stock in observational studies regarding sex hormones, the majority of the are written based on hormonophobia and have been proven wrong in RCTs.
2026-07-29 19:27:01
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