Harry K-P | Shes Not Crazy :
📌 The evidence:
🧬 The two-crash structure of the female cycle: mid-late luteal estrogen and testosterone drop (approximately 50-85% between late-luteal peak and menstruation), followed by a sharp late-luteal progesterone withdrawal in the 3-5 days before menstruation: Reed & Carr, 2018, Endotext (NCBI); Barbieri, 2014, Yen & Jaffe’s Reproductive Endocrinology, 7th ed.
🧬 The 125-year male hormonal comparison derived from Harman et al., 2001, Journal of Clinical Endocrinology & Metabolism (male testosterone decline ~1% per year from age 30)
🧬 Late-luteal progesterone withdrawal and its neurological effects: Bäckström et al., 2011, Neuroscience & Biobehavioral Reviews; Sundström Poromaa & Gingnell, 2014, Frontiers in Neuroscience
🧬 Serotonin and GABA changes in the late luteal phase driving mood and irritability symptoms: Halbreich et al., 2003, Psychoneuroendocrinology; Rapkin & Winer, 2009, Expert Opinion on Pharmacotherapy
🧬 Cognitive and emotional regulation impacts across the cycle: Le et al., 2020, Frontiers in Behavioral Neuroscience; Sundström Poromaa & Gingnell, 2014, Frontiers in Neuroscience
🧬 Reduced emotional inhibition and increased emotional expression in the late luteal phase: Andreano & Cahill, 2010, Learning & Memory; Ossewaarde et al., 2013, Journal of Neuroscience
🧬 PMS prevalence approximately 75% of women, PMDD prevalence 3-8%: American College of Obstetricians and Gynecologists; Halbreich et al., 2003
🧬 Historical dismissal of premenstrual symptoms in medical and cultural contexts: Ussher, 2013, Feminism & Psychology; Chrisler & Caplan, 2002, Annual Review of Sex Research
🧬 If you want the full biology walkthrough of the first crash, watch: MANSPLAINING The Luteal Phase (pinned to my grid).
2026-07-30 06:33:09