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Friday 07 August 2026 23:26:13 GMT
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itsrobbietime :
what about an orexin antagonist
2026-08-08 12:25:23
0
jroon :
Absolute terrible news for narapolpsy, they had a free excuse to be able to get ghb and amphetamines now they about to have to take shit orixin antagonists I would be PISSED
2026-08-08 02:06:56
18
Jonah :
sad that it didnt work for IH, but i know there are others
2026-08-08 11:49:36
3
scientific sean :
:0 (i’d kill to hear your thoughts on centanafadine haha)
2026-08-08 13:15:22
10
lopez_victor11 :
Why does a deficiency in orexin cause narcolepsy?
2026-08-08 06:05:05
1
mika :
as someone with narcolepsy who has been following this for a while im excited but keeping my expectations low. its not a cure as some publications have been framing it, just a treatment that is more direct than traditional stimulants. i had a friend with narcolepsy who took part in a clinical trial and had told me the medication felt just like trying modafinil for the first time again (not worse but not any better) but im assuming the good thing about this med is the body doesnt build tolerance too it as fast meaning you can stay on it for longer. for now i still think sodium oxybates have been the most important development in treating narcolepsy but we will see
2026-08-08 12:29:36
4
trumpspusseequeef :
So if I take this alongside Belsomra will my body take a screenshot?
2026-08-08 16:39:49
6
Ari The Reborn :
Isn’t Modafinil a partial orexin agonist?
2026-08-08 17:50:25
1
Colin :
sooooo the opposite of the orexin based hypnotics? that’s so cool that we came up with both in such a short timeframe
2026-08-20 12:27:36
2
amadeus :
Sleep apnea daytime sleepiness?
2026-08-08 15:43:31
0
🇦🇹 :
Horrible news for the narcolepsy community. No more dexamphetamine😂.
2026-08-11 00:40:11
2
aidan :
brother what do you know about the cyp2d6 liver enzyme and stims
2026-08-08 00:08:16
1
·☽ Avery 𖤓 Halliwell ☾· :
it obviously is going to have a wakefulness/ stimulating effect because its doing the exact opposite of the orexin meds for sleep lol.
2026-08-08 01:52:04
2
gearfish :
So sick
2026-08-07 23:38:01
5
Tim :
Yada yada yada, source?
2026-08-08 15:27:46
0
kdw :
interesting. waiting for more research being published about it and its efficacy in the treatment of other non-sleep disorders
2026-08-08 05:39:45
1
Beautiful Zoro :
This is super interesting! I’m very curious about how it will affect those non narcoleptic groups. Also I wanted to ask if you would be able to do a video on pcp cardiotoxicity (or toxicity in general) and whether one could assume analogues would also have similar effects?
2026-08-08 01:16:12
0
Nevaeh 💖 :
This is super exciting. I've been following the research on orexin agonists for narcolepsy for about a decade and it's been awesome to see the development come to fruition. Compared to placebo it had truly fantastic results, huge win for the narcolepsy community
2026-08-08 09:41:01
2
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