@biomaxxer: SSRIs, neurogenesis, NSI-189 and the wrong target for depression? Now, I’m not saying NSI is proof for ADN and SSRIs are not, but at the very least, this is a potentially much less destructive compound and a promising development for depression and cognitive enhancement (they go hand in hand as I’ve shown.) No beef with SSRI users! Also shout out @Julian as his takes on SSRIs are antithetical to mine and I think you guys should see both sides. #pharmacology #biohacking #neuroscience #nootropics #ssri
i’ve been on ssris snris and mood stabilizers since 16 to treat bpd and major depressive disorder caused by extremely low testosterone and let me tell you my brain has never been close to as sharp as before i got on ssris when i first started ssris it felt like i had just a chunck of my brain turned off
2026-08-08 05:28:01
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juublian.neuro :
Haha this is a good video, I like discussing both sides here (unless it’s bioscience). I’ll make a stitch soon, but I do think you have a point about more “direct” drugs being more favorable. I wouldn’t be surprised if SSRIs got outclassed by more targeted selective drugs in 30-50 years. The only issue here is the lack of data with these more targeted drugs; they don’t have the 40 years of post-clinical data like SSRIs do. Mechanistic data only goes so far, but it’s important to see all facets here.
2026-08-08 04:40:25
24
Harryd :
What about serataline
2026-08-08 13:41:47
9
vadtaf :
Is Wellbutrin harmful
2026-08-08 05:22:18
1
ger :
Idk I don’t like how much hate antidepressant get cz not everyone even gets those side effects. I’ve tried many antidepressants and I like them quit max dose duloxetine over a year ago and it was fine lowkey needed help again started venlafaxine 2 weeks ago. they just not bad imo way better than depending on benzos and truly help people they not just destructive
2026-08-08 12:26:59
3
rahimrahim6105 :
peat said no
2026-08-09 14:16:22
4
Sixth :
Every time I sweat or get hot it feels like I’m being skinned because of taking SSRIs for so long, I don’t even take them anymore too 💔
2026-08-08 23:50:51
3
jzqvns :
i thought ssris cause brain shrinkage/is extremely bad for your brain or am i mistaking it for benzo’s/anxiety meds/antipsychotics
2026-08-20 06:12:40
3
nelson1236638 :
My friends been on ssris for half his life would that have made him smarter
2026-08-09 08:58:40
1
Nach :
Isn’t that leo video like 4 years old as well
2026-08-08 22:31:01
3
Bekind :
We need a new podcast bro
2026-08-08 13:05:58
1
perimeter :
wasn't he using it for sigma 1 agonism more so?
2026-08-19 18:41:42
1
Andymor :
I got on fluvox and everything felt better . Look up the dominance hierarchy and serotonin and I found a bunch of studies that show wayy more increase in neurogenesis . Normally I like his videos but this isn’t the best take.
2026-08-11 17:02:19
4
Professor X One Trick :
is pervitin harmful?
2026-08-28 15:09:13
2
reckless savage :
thanks for the info bio
2026-08-08 09:00:04
17
Nate Higgerson :
ascending in real time
2026-08-21 05:51:45
1
3bdi🪖 :
Neurogenesis does happen in adult hood but much slower compared to developing brains
2026-08-09 15:58:39
2
d4turatr1p :
I used lexapro and went manic
2026-08-18 22:15:03
1
femboycatboy :
i tried few different SSRIs that psychiatrists gave me and they suck soooo damn much
2026-08-19 19:21:29
1
Alex :
Neurogenesis appear not because of the drug itself. It doesn’t appear from the drug itself not in a drug called vortioxetine which is known to help the brain more than the other antidepressants. It appears because of the nervous system resting and learning new coping mechanisms. It is that simple
2026-08-09 08:54:58
2
Beaz:) :
Bump
2026-08-08 05:47:20
2
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