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If you’re reading this as someone struggling with inflammatory bowel disease (IBD), you’ve probably experienced a time when stress made your symptoms worse or triggered a flare-up. But why? A study published last month¹ uncovered exactly how chronic stress can inflame the gut and worsen conditions like IBD. 👇 1️⃣ When you’re stressed, your brain produces chemical cues that signal the adrenal glands. 2️⃣ In response, the adrenal glands release hormones called glucocorticoids that act on neurons and glial cells (cells that connect neurons to one another) in your gut. This stimulates the release of molecules that trigger immune cells. 3️⃣ Immune cells then release molecules that are typically used to fight off harmful microbes, but end up causing painful bowel inflammation in people with IBD. 4️⃣ At the same time all of this is going on, glucocorticoids slow down food movement, leading to even more discomfort. It was surprising 😯 to find that glucocorticoids are the main culprit of gut inflammation because these compounds are actually used as a treatment for IBD. Researchers hypothesized that glucocorticoids are anti-inflammatory in short bursts, but chronic stress shifts their role, so they become pro-inflammatory. This discovery suggests that the combination of stress management practices with traditional IBD treatments like drugs could be more effective than drugs alone. 🤝 And the implications extend beyond IBD. This research provides another example of the intricate and profound connection between the gut and the brain (known as the gut-brain axis 🧠). As research continues to identify gut-brain pathways like this, we can unlock new avenues to manage or treat a wide range of gastrointestinal and neurological conditions. What are your go-to methods to manage stress? Share with the group. • ¹ Schneider, K. M., Blank, N., Alvarez, Y., Thum, K., Lundgren, P., Litichevskiy, L., Sleeman, M., Bahnsen, K., Kim, J., Kardo, S., Patel, S., Dohnalová, L., Uhr, G. T., Descamps, H. C., Kircher, S., McSween, A. M., Ardabili, A. R., Nemec, K. M., Jimenez, M. T., Glotfelty, L. G., … Thaiss, C. A. (2023). The enteric nervous system relays psychological stress to intestinal inflammation. Cell, S0092-8674(23)00475-0. Advance online publication. https://doi.org/10.1016/j.cell.2023.05.001

If you’re reading this as someone struggling with inflammatory bowel disease (IBD), you’ve probably experienced a time when stress made your symptoms worse or triggered a flare-up. But why? A study published last month¹ uncovered exactly how chronic stress can inflame the gut and worsen conditions like IBD. 👇 1️⃣ When you’re stressed, your brain produces chemical cues that signal the adrenal glands. 2️⃣ In response, the adrenal glands release hormones called glucocorticoids that act on neurons and glial cells (cells that connect neurons to one another) in your gut. This stimulates the release of molecules that trigger immune cells. 3️⃣ Immune cells then release molecules that are typically used to fight off harmful microbes, but end up causing painful bowel inflammation in people with IBD. 4️⃣ At the same time all of this is going on, glucocorticoids slow down food movement, leading to even more discomfort. It was surprising 😯 to find that glucocorticoids are the main culprit of gut inflammation because these compounds are actually used as a treatment for IBD. Researchers hypothesized that glucocorticoids are anti-inflammatory in short bursts, but chronic stress shifts their role, so they become pro-inflammatory. This discovery suggests that the combination of stress management practices with traditional IBD treatments like drugs could be more effective than drugs alone. 🤝 And the implications extend beyond IBD. This research provides another example of the intricate and profound connection between the gut and the brain (known as the gut-brain axis 🧠). As research continues to identify gut-brain pathways like this, we can unlock new avenues to manage or treat a wide range of gastrointestinal and neurological conditions. What are your go-to methods to manage stress? Share with the group. • ¹ Schneider, K. M., Blank, N., Alvarez, Y., Thum, K., Lundgren, P., Litichevskiy, L., Sleeman, M., Bahnsen, K., Kim, J., Kardo, S., Patel, S., Dohnalová, L., Uhr, G. T., Descamps, H. C., Kircher, S., McSween, A. M., Ardabili, A. R., Nemec, K. M., Jimenez, M. T., Glotfelty, L. G., … Thaiss, C. A. (2023). The enteric nervous system relays psychological stress to intestinal inflammation. Cell, S0092-8674(23)00475-0. Advance online publication. https://doi.org/10.1016/j.cell.2023.05.001

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