@simplifying.drug: Fosfomycin vs. UnComplicated UTIs! 🧪 One dose to shut down bacterial cell wall assembly before it even starts. Here is the pharmacology behind this powerful antibiotic. Educational content only not a medical ADVICE #pharmacy #nursingstudent #medicalstudent #doctor #viralvideos

Eggar-10 :

alternative drugs for uncomplicated UTI, when fosfomycin is out of stock

Simplifying Drug :

Explanation: Fosfomycin is a broad-spectrum antibiotic with a unique mechanism of action that sets it apart from other cell wall inhibitors like beta-lactams and glycopeptides:Mechanism of Action: Fosfomycin acts as a phosphoenolpyruvate (PEP) analog that irreversibly inhibits the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA). MurA catalyzes the very first committed step in bacterial peptidoglycan cell wall synthesis. By blocking MurA, fosfomycin prevents the formation of N-acetylmuramic acid, causing cell lysis and bacterial death.Spectrum & Clinical Role: It exhibits potent bactericidal activity against common urinary pathogens, including multidrug-resistant (MDR) strains like extended-spectrum\beta-lactamase (ESBL)-producing E. coli and Enterococcus faecalis.Uncomplicated vs. Complicated UTI: While a single oral 3 gm dose of fosfomycin tromethamine is FDA-approved for uncomplicated cystitis in women, its role in complicated UTIs (e.g., pyelonephritis, catheter-associated UTIs, or infections in male patients) often requires multi-dose regimens or intravenous formulations due to tissue penetration dynamics and systemic involvement. educational content only not a medical ADVICE

batoode :

do for me dienogest please 😁

Z khalil 😎 :

before you take fosfomycin, do Urine c/s if sensitive to fosmoycin than take it

Bil Santos :

Is it safe in pregnant mother's?

🩺 :

hhh good concept

Esther ❤️ :

Now.. This is some good information

jhone :

what about complicated UTi ?

𝐏𝐚𝐩𝐢𝐜𝐨𝐧𝐭𝐫𝐨𝐨𝐡 :

Nkululeko Simamane :

is fosfomycin a true antibiotic?

Shahbaz Jamal official :

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Waqar Khan :

❤️❤️❤️

Abdullah Amir5207 :

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Anesthesiologist 💉🧠 :

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munirkhan0390 :

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Jãwãd såfî162 :

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Maghaz Ali 🥰🥰 :

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Irfan chamkani :

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Aqeel :

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~>INTROVERT<~ :

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Vet Dr.Asim (DVM) :

💕💕💕

Danyal_shadab💫 :

💓💓💓

Doctor Shoaib :

[Tears of joy][Tears of joy][Tears of joy]

@cptkaka10❤️ :

😂😂😂