@robertlufkin: As a medical school professor, I remind patients that cancer is not only a genetic disease — it is also a metabolic one. A new preclinical Nature Metabolism study out of Weill Cornell made that concrete in prostate cancer. Dr. John Blenis and colleagues showed that propionyl-CoA — produced when your body breaks down the branched-chain amino acids isoleucine and valine — acts as a signal that switches on cholesterol production inside prostate cancer cells. That extra cholesterol helps the cancer adapt to hormone-deprivation therapy and become more aggressive. A byproduct of everyday amino-acid metabolism is feeding treatment resistance. Study honesty: this is preclinical work in cells, not a clinical trial. It adds another data point to the metabolic-root-cause thesis I lay out in "Lies I Taught in Medical School": chronic disease and cancer progression are shaped by the fuel we run our cells on, not just the mutations we inherit. Full breakdown coming on the Health Longevity Secrets podcast https://www.youtube.com/@RobertLufkinMD Source: https://metabolichealth.weill.cornell.edu/ #MetabolicHealth #HealthLongevitySecrets #ProstateCancer #Metabolism #Longevity

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Saturday 29 August 2026 00:01:06 GMT